This paper describes two patients, O.I. and B.Y., with a confabulatory syndrome. O.I. was diagnosed with probable fronto-temporal dementia, whereas B.Y. met the criteria for probable Alzheimer's disease. O.I., but not B.Y., was impaired on tests of frontal/executive functions, and performed better than B.Y. on clinical tests of memory. Both patients confabulated in episodic/autobiographical memory tasks and in personal future planning tasks. B.Y. confabulated also in a semantic memory task. It is argued that the pattern of confabulation and the cognitive profile shown by the two patients is explained better by the hypothesis proposed by Dalla Barba and co-workers (Dalla Barba et al., 1997b) than by current theories of confabulation.
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http://dx.doi.org/10.1016/s0010-9452(08)70538-0 | DOI Listing |
J Neurol
January 2025
Centre de Génétique Humaine, Centre Hospitalier Universitaire de Besançon, Besançon, France.
Introduction: The MAPT gene encodes Tau, a protein mainly expressed by neurons. Tau protein plays an important role in cerebral microtubule polymerization and stabilization, in axonal transport and synaptic plasticity. Heterozygous pathogenic variation in MAPT are involved in a spectrum of autosomal dominant neurodegenerative diseases known as taupathies, including Alzheimer's disease, Pick's disease, fronto-temporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
View Article and Find Full Text PDFBrain Res Bull
January 2025
Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK; School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK. Electronic address:
Recent clinical trials targeting tau protein aggregation have heightened interest in tau-based therapies for dementia. Success of such treatments depends crucially on translation from non-clinical animal models. Here, we present the age profile of the PLB2 knock-in model of fronto-temporal dementia in terms of cognition, and by utilising a directly translatable magnetic resonance imaging approach.
View Article and Find Full Text PDFRev Med Suisse
October 2024
Service de gériatrie, Centre hospitalier universitaire vaudois, 1011 Lausanne.
This article explores the diagnosis of Mild Cognitive Impairment (MCI) in general practice. It examines the subtypes of MCI and their specific diagnostic criteria for different neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease, fronto-temporal dementia and cerebrovascular disorders. It highlights the preferential use of the Montreal Cognitive Assessment (MoCA) over the Mini-Mental State Examination (MMSE) for detecting MCI.
View Article and Find Full Text PDFInt J Geriatr Psychiatry
October 2024
Department of Psychology, Bournemouth University, Poole, UK.
Life (Basel)
September 2024
Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.
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