This paper describes two patients, O.I. and B.Y., with a confabulatory syndrome. O.I. was diagnosed with probable fronto-temporal dementia, whereas B.Y. met the criteria for probable Alzheimer's disease. O.I., but not B.Y., was impaired on tests of frontal/executive functions, and performed better than B.Y. on clinical tests of memory. Both patients confabulated in episodic/autobiographical memory tasks and in personal future planning tasks. B.Y. confabulated also in a semantic memory task. It is argued that the pattern of confabulation and the cognitive profile shown by the two patients is explained better by the hypothesis proposed by Dalla Barba and co-workers (Dalla Barba et al., 1997b) than by current theories of confabulation.

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0010-9452(08)70538-0DOI Listing

Publication Analysis

Top Keywords

fronto-temporal dementia
8
alzheimer's disease
8
dalla barba
8
confabulation patient
4
patient fronto-temporal
4
dementia patient
4
patient alzheimer's
4
disease paper
4
paper describes
4
describes patients
4

Similar Publications

Introduction: The MAPT gene encodes Tau, a protein mainly expressed by neurons. Tau protein plays an important role in cerebral microtubule polymerization and stabilization, in axonal transport and synaptic plasticity. Heterozygous pathogenic variation in MAPT are involved in a spectrum of autosomal dominant neurodegenerative diseases known as taupathies, including Alzheimer's disease, Pick's disease, fronto-temporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

View Article and Find Full Text PDF

PLB2 mice are impaired in novel and temporal object recognition and show corresponding traits in brain MRI.

Brain Res Bull

January 2025

Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK; School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK. Electronic address:

Recent clinical trials targeting tau protein aggregation have heightened interest in tau-based therapies for dementia. Success of such treatments depends crucially on translation from non-clinical animal models. Here, we present the age profile of the PLB2 knock-in model of fronto-temporal dementia in terms of cognition, and by utilising a directly translatable magnetic resonance imaging approach.

View Article and Find Full Text PDF

This article explores the diagnosis of Mild Cognitive Impairment (MCI) in general practice. It examines the subtypes of MCI and their specific diagnostic criteria for different neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease, fronto-temporal dementia and cerebrovascular disorders. It highlights the preferential use of the Montreal Cognitive Assessment (MoCA) over the Mini-Mental State Examination (MMSE) for detecting MCI.

View Article and Find Full Text PDF
Article Synopsis
  • A systematic review was conducted to explore the issue of misdiagnosis in dementia, particularly focusing on rarer subtypes that may struggle more with accurate diagnosis compared to common types like Alzheimer's.
  • The review included 20 studies and identified four main themes: factors contributing to misdiagnosis, challenges in the diagnostic process, economic implications, and personal experiences of individuals facing delayed diagnoses.
  • There is a critical need for further research on the emotional and monetary effects of dementia misdiagnosis on patients, caregivers, and the healthcare system to improve clinical practices.
View Article and Find Full Text PDF

The Microbiota-Gut-Brain Axis and Neurological Disorders: A Comprehensive Review.

Life (Basel)

September 2024

Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.

Article Synopsis
  • * Research over the past 20 years shows that the MGBA significantly affects various neurological diseases, including Alzheimer's, autism, ADHD, and others.
  • * Understanding the MGBA can lead to new microbial-based treatments for these neurological conditions, as factors like diet, exercise, and medication can impact this communication pathway.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!