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From Concept to Cure: The Evolution of CAR-T Cell Therapy.
Mol Ther
March 2025
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, 19104, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Chimeric antigen receptor (CAR)-T cell therapy has revolutionized cancer immunotherapy in the 21 century, providing innovative solutions and life-saving therapies for previously untreatable diseases. This approach has shown remarkable success in treating various hematologic malignancies and is now expanding into clinical trials for solid tumors, such as prostate cancer and glioblastoma, as well as infectious and autoimmune diseases. CAR-T cell therapy involves harvesting a patient's T cells, genetically engineering them with viral vectors to express CARs targeting specific antigens and reinfusing the modified cells into the patient.
View Article and Find Full Text PDFElectrochemical cobalt-catalyzed semi-deuteration of alkynes to access deuterated Z-alkenes.
Nat Commun
March 2025
State Key Laboratory of Precision and Intelligent Chemistry, University of Science and Technology of China, Hefei, China.
Deuterium labeling has found extensive applications across various research fields, including organic synthesis, drug design, and molecular imaging. Electrocatalytic semi-hydrogenation of alkynes offers a viable route for the synthesis of Z-alkenes, yet it falls short in achieving the semi-deuteration of these compounds. In this study, we report an electrochemical cobalt-catalyzed transfer deuteration reaction that proficiently accomplishes the semi-deuteration of alkynes, yielding Z-configuration deuterated alkene products.
View Article and Find Full Text PDFThe impact of digital transformation on open innovation performance: The intermediary role of digital innovation dynamic capability.
PLoS One
March 2025
Tianjin University, Economics School, Tianjin, Peoples R China.
In the context of digital economy, both the process and boundaries of open innovation performance are changing, and digital transformation has become an important factor for enterprises to realize open innovation performance in a complex and changing environment. This study based on the dynamic capability theory, etc. to explore how digital transformation drives the open innovation performance of enterprises and analyze its impact effects as well as the internal mechanism of action.
View Article and Find Full Text PDFExploring the Antibacterial and Antifungal Efficacy of Herbal Plants: An Ayurvedic Research.
J Pharm Bioallied Sci
December 2024
Department of Prosthodontics and Crown and Bridge, Madha Dental College, Chennai, Tamil Nadu, India.
Context: Nature has endowed humanity with a vast repository of remedies that have been use for ages to heal all sorts of ailments.
Aim: To evaluate the antibacterial and antifungal efficacy of three herbal plants (Justicia adhatoda, Glycyrrhiza glabra, and Punica granatum), on three microorganisms (Streptococcus mutans, Staphylococcus aureus, and Candida albicans) that are present in the oral stoma.
Settings And Design: microbial study.
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