AI Article Synopsis
- A new and cost-effective bioluminescent assay has been created to detect catalytic antibodies, which can help in early diagnosis.
- This method utilizes the luminescent bacterium VhM42 to track specific reactions involving aldolase antibodies.
- The technique demonstrates high sensitivity and ease of use in monitoring antibody activity.
Article Abstract
A highly sensitive, inexpensive, and facile bioluminescent assay for the detection of catalytic antibodies has been developed. This assay may be used for the early detection of antibody catalysis. The efficiency of this technique was exemplified by the use of the luminescent bacterium VhM42 for monitoring an antibody-catalyzed retroaldol fragmentation reaction with aldolase antibodies 38C2 and 24H6.
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| http://dx.doi.org/10.1016/s0960-894x(00)00455-8 | DOI Listing |
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