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Molecular mechanism of osteoclast differentiation of PBMC in patients with rheumatoid arthritis.
Clin Rheumatol
January 2025
Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou Province, China.
Objective: Rheumatoid arthritis (RA) is an autoimmune condition that causes severe joint deformities and impaired functionality, affecting the well-being and daily life of individuals. Consequently, there is a pressing demand for identifying viable therapeutic targets for treating RA. This study aimed to explore the molecular mechanisms of osteoclast differentiation in PBMC from patients with RA through transcriptome sequencing and bioinformatics analysis.
View Article and Find Full Text PDFThe Role of Platelet-Neutrophil Interactions in Driving Autoimmune Diseases.
Immunology
January 2025
Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China.
Platelets and neutrophils are among the most abundant cell types in peripheral blood. Beyond their traditional roles in thrombosis and haemostasis, they also play an active role in modulating immune responses. Current knowledge on the role of platelet-neutrophil interactions in the immune system has been rapidly expanding.
View Article and Find Full Text PDFThe effects of intermittent fasting on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with rheumatoid arthritis: a randomized controlled trial.
Sci Rep
January 2025
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O. Box 14155-6117, Tehran, Iran.
Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting postmenopausal women. This study investigated the effects of intermittent fasting (IF) on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with RA. This 8-week randomized controlled trial included 44 postmenopausal women with RA divided into an intervention group following a 16:8 IF diet and a control group maintaining their usual diet and received recommendations for healthy eating.
View Article and Find Full Text PDFPruritic eruption associated with rheumatoid arthritis: rheumatoid neutrophilic dermatitis.
BMJ Case Rep
January 2025
Department of Dermatology, Mayo Clinic in Florida, Jacksonville, Florida, USA
Pyoderma Gangrenosum With Severe Ankle Ankylosis Complicated by Rheumatoid Arthritis Successfully Treated Using Anti-tumor Necrosis Factor: A Case Report.
Cureus
December 2024
Department of Orthopaedic Surgery, Yamagata University Faculty of Medicine, Yamagata, JPN.
Pyoderma gangrenosum (PG) is a rare dermatosis characterised by necrotic ulcers with a predilection mainly for the lower legs. We report a case of a 67-year-old man with PG and severe ankle ankylosis complicated by rheumatoid arthritis (RA) treated with anti-tumor necrosis factor, adalimumab (ADA). He was referred to our hospital because his right ankle showed severe ulcers and blackening.
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