Pathological angioarchitecture in lymph nodes: underlying histopathologic findings.

Ultrasound Med Biol

Department of Radiology, University of Wuerzburg, Wuerzburg, Germany.

Published: September 2000

Pathologic changes of the intranodal angioarchitecture, as displayed by colour Doppler sonography, were used in recent studies to predict malignant infiltration of superficial lymph nodes. We searched for the underlying histopathologic findings in a prospective study including 100 lymph nodes in 86 patients. In the histopathologic specimens, we evaluated tumour infiltration, distribution of intranodal vessels, hilar structures, thickness of the capsule and tissue alterations (necrosis, sclerosis, lipo-/fibromatosis). Using the only prospectively tested classification, a pathologic angioarchitecture was described as displacement, aberrant course, avascular foci or subcapsular vessels. Testing these four criteria by multivariate regression analysis, the most important correlations were found between the following pairs of sonographic and histopathologic findings: displacement with perinodal tumour spread, aberrant vessels with intranodal sclerosis, avascular foci with intranodal necroses and subcapsular vessels with intranodal necroses. In conclusion, the criteria describing a pathologic angioarchitecture correlate with histopathologic findings that are frequently seen in malignant lymph nodes.

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0301-5629(00)00221-0DOI Listing

Publication Analysis

Top Keywords

lymph nodes
16
histopathologic findings
16
underlying histopathologic
8
pathologic angioarchitecture
8
avascular foci
8
subcapsular vessels
8
vessels intranodal
8
intranodal necroses
8
histopathologic
5
intranodal
5

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!