AI Article Synopsis
- Lithium is effective for treating manic episodes and preventing bipolar disorder, with few reported side effects at therapeutic levels.
- A case study describes a 38-year-old woman who experienced disorientation and memory deficits after 20 years of successful lithium treatment, following a manic episode.
- These psychiatric symptoms resolved after discontinuing lithium, suggesting the possibility of a delirium-like syndrome with pseudo-dementia, highlighting the need to monitor for such side effects in long-term lithium patients.
Article Abstract
Lithium is used with great success in the treatment of manic patients and for prophylaxis of bipolar disorders. There are only few reports about neuropsychiatric side effects at therapeutic serum levels. We report on a 38 year old woman with bipolar disorder who was treated with lithium for 20 years without side-effects. Subsequent to a manic episode, she became disoriented at night and showed marked memory deficits. The patient did not show any neurological or gastrointestinal signs of intoxication. Lithium serum-levels were in therapeutic range. The psychiatric symptoms disappeared when lithium was stopped. We interpret these symptoms as delirant syndrome with pseudo-dementia at therapeutic lithium serum levels. This side-effect must be taken into account even in patients on successful longtime lithium therapy.
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