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Interplay of Light, Melatonin, and Circadian Genes in Skin Pigmentation Regulation.
Pigment Cell Melanoma Res
January 2025
Department of Cell Biology and Anatomy, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada.
Circadian regulation of skin pigmentation is essential for thermoregulation, ultraviolet (UV) protection, and synchronization of skin cell renewal. This regulation involves both cell-autonomous photic responses and non-cell-autonomous hormonal control, particularly through melatonin produced in a light-sensitive manner. Photosensitive opsins, cryptochromes, and melatonin regulate circadian rhythms in skin pigment cells.
View Article and Find Full Text PDFVisualizing the spatial distribution of Alprazolam in the mouse brain following nasal administration using desorption electrospray ionization mass spectrometry imaging.
Int J Pharm
January 2025
School of Pharmacy, Guilin Medical University, Guilin, Guangxi 541199, China. Electronic address:
Alprazolam (Alp), a triazolobenzodiazepine, is widely prescribed for the treatment of sleep disorders, anxiety, and panic disorder. While oral administration remains the standard route, its slow onset of action has prompted interest in intranasal delivery as an alternative, offers the potential for direct drug delivery to the brain. This study aims to develop a fast-acting intranasal formulation of Alp (Alp-nd).
View Article and Find Full Text PDFData Mining Approach to Melatonin Treatment in Alzheimer's Disease: New Gene Targets and .
Int J Mol Sci
January 2025
Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China.
Melatonin is a hormone released by the pineal gland that regulates the sleep-wake cycle. It has been widely studied for its therapeutic effects on Alzheimer's disease (AD), particularly through the amyloidosis, oxidative stress, and neuroinflammation pathways. Nevertheless, the mechanisms through which it exerts its neuroprotective effects in AD are still largely unknown.
View Article and Find Full Text PDFChronic Dexamethasone Disturbs the Circadian Rhythm of Melatonin and Clock Genes in Goats.
Animals (Basel)
January 2025
Key Laboratory of Animal Physiology & Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Article Synopsis
- Dex, a drug used for its immunosuppressive and anti-inflammatory effects, disrupts melatonin secretion and biological clock gene expression in goats.
- After 21 days of Dex treatment, goats showed significantly lower melatonin levels in both plasma and colon, as well as decreased expression of AANAT, a key enzyme for melatonin synthesis.
- The circadian rhythms of several clock genes were disrupted in the Dex group, along with notable changes in CLOCK and BMAL1 protein levels, indicating that chronic Dex exposure affects biological rhythm regulation.
Purpose: Although fluoride is known to be effective and safe, an increasing number of parents refuse to allow fluoride applications for their children. This study aimed to compare the parents who accepted and rejected fluoride application for their children in terms of their attitudes toward fluoride and vaccinations, sociodemographic characteristics, and source of knowledge.
Materials And Methods: In this cross-sectional study, a previously validated questionnaire was administered to 85 parents who did not consent to have topical fluoride applied to their children's teeth (AF group) and the 143 parents who consented to have it applied (F group) in a pediatric dentistry clinic.
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