A general probabilistic technique for estimating background contributions to measured spectra is presented. A Bayesian model is used to capture the defining characteristics of the problem, namely, that the background is smoother than the signal. The signal is allowed to have positive and/or negative components. The background is represented in terms of a cubic spline basis. A variable degree of smoothness of the background is attained by allowing the number of knots and the knot positions to be adaptively chosen on the basis of the data. The fully Bayesian approach taken provides a natural way to handle knot adaptivity and allows uncertainties in the background to be estimated. Our technique is demonstrated on a particle induced x-ray emission spectrum from a geological sample and an Auger spectrum from iron, which contains signals with both positive and negative components.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1103/physreve.61.1152 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pressure Sensor Array Based on Four DNA-Nanoenzymes with Catalase-like Activity for Portable Multiple Detection of Foodborne Pathogens.
J Agric Food Chem
January 2025
Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China.
This study has developed a pressure sensor array based on four functionalized DNA-nanoenzymes with catalase-like activity for multiple detections of foodborne pathogens through a portable pressure manometer. Benefiting from functionalization of 4-mercaptophenylboronic acid and β-mercaptoethylamine, the diversity of nonspecific interactions between four DNA-nanoenzymes and each of the nine bacteria leads to differences in pressure response patterns by catalyzing HO to generate exclusive "fingerprints". As effective statistical tools for processing multivariate data, principal component analysis and hierarchical clustering analysis are employed to identify nine foodborne pathogens by analyzing pressure response patterns.
View Article and Find Full Text PDFStriving for Unity in a Culturally Fragmented World: Nested Multiple Cultural Identifications Associated With Well-Being Through Self-Concept Clarity.
Int J Psychol
February 2025
Department of Psychology, University of Texas at Austin, Austin, Texas, USA.
In contemporary globalised societies, global awareness and identification, as well as local and regional identifications (other than national identity), may all become increasingly important for guiding people's sense of belonging and purpose and in turn their self-concept. As the world has become increasingly interconnected, people increasingly identify with various cultures and worldviews within both local and global contexts. Attempts to reconcile these multiple cultural identities can lead to a sense of cultural dissonance as people struggle to integrate these identities into a coherent sense of self.
View Article and Find Full Text PDFDesign and validation of the reflection skills self-assessment questionnaire (RSSAQ).
J Educ Health Promot
November 2024
Medical Education Research Center, Medical Education Department, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Background: Reflection is one of the main components of the medical sciences curriculum. It is one of the learner-centered educational strategies, leading to deep learning, and is necessary to attain professional capabilities. A pertinent challenge is how to assess reflection.
View Article and Find Full Text PDFPrimary Sacral Activated B-Cell Like Diffuse Large B-Cell Lymphoma, Triple Expressor Type: A Case Report with Literature Review.
J Microsc Ultrastruct
December 2022
Department of Pathology, IMS and SUM Hospital, Bhubaneswar, Odisha, India.
Primary bone lymphomas are unusual, and accounts for 2% among all lymphomas. Primary sacral lymphomas are still rarer with only 12 cases reported till date. They predominantly affect elderly males, showing occasional spinal epidural space involvement.
View Article and Find Full Text PDFA responsive cocktail nano-strategy breaking the immune excluded state enhances immunotherapy for triple negative breast cancer.
Nanoscale
January 2025
Department of Oncology, Shanghai East Hospital, School of Medicine, Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai 200092, China.
The exclusion of immune cells from the tumor can limit the effectiveness of immunotherapy in triple negative breast cancer (TNBC). The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway plays a crucial role in priming adaptive anti-tumor immunity through the production of type I interferons (IFNs), facilitating the maturation of dendritic cells (DCs) and the function of T cells. Although the increased expression of programmed death-ligand 1 (PD-L1) upon STING activation is favorable for amplifying the efficacy of immune checkpoint inhibitors (ICIs) and realizing combination therapy, the penetration barrier remains a major obstacle.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!