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Nodular Hidradenoma With Atypical Features in a Young Patient: A Case Report.
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December 2024
Saudi Internal Medicine Residency Training Program, Ministry of Health, Jeddah, SAU.
Eccrine acrospiromas, also known as hidradenomas, are rare benign tumors that develop from the eccrine sweat glands. Hidradenoma is a multilobular, nonencapsulated, well-circumscribed dermal nodule that may involve the epidermis and extend into the subcutaneous fat. The etiology and prevalence of nodular hidradenoma are not well defined, but it is noted that it can occur spontaneously or traumatically.
View Article and Find Full Text PDFEpstein-Barr virus-associated smooth muscle tumor with multiple lesions in a patient with AIDS.
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March 2025
Department of Infectious Disease, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Epstein-Barr virus-associated smooth muscle tumors (EBV-SMTs) represent a rare category of soft tissue tumors that are predominantly seen in individuals with compromised immune systems. Pathologically, EBV-SMT has malignant potential because of its unpredictable nature. These tumors can manifest at various anatomical sites or even multiple lesions in different locations.
View Article and Find Full Text PDFChemo-Mechanical Due-Biomimetic Approach for Ultra-Stable Adsorption Across Multiple Scenarios.
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January 2025
School of Chemistry and Materials, Department of Chemistry, Laboratory of Advanced Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, P. R. China.
The unique adhesion capabilities of soft-bodied creatures such as leeches and octopuses have provided considerable inspiration for the development of artificial adhesive materials. However, previous studies have either focused on the design of sucker structures or concentrated on the synthesis of adhesive materials, with the combination of these two aspects not yet having been deeply investigated. In this study, inspired from leech's unique adsorption ability, a biomimetic approach is proposed that combined artificial sucker and mucus, to achieve remarkable adhesion stability on rough surfaces using 5 cm diameter silicone suction cups.
View Article and Find Full Text PDFPediatric-type Myoid Neoplasms of Somatic Soft Tissue: A Clinicopathological and Molecular Genetic Study of 78 Tumors, Highlighting Indolent Clinical Behavior and Frequent SRF Gene Rearrangements.
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Department of Pathology, Boston Children's Hospital, Boston, MA, 02115 USA. Electronic address:
Soft tissue tumors with smooth muscle differentiation are rare in pediatric patients. Despite often showing morphologic features sufficient for classification as "leiomyosarcoma" in adults (e.g.
View Article and Find Full Text PDFSuppression of METTL3 expression attenuated matrix stiffness-induced vaginal fibroblast-to-myofibroblast differentiation and abnormal modulation of the extracellular matrix in pelvic organ prolapse.
Chin Med J (Engl)
January 2025
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing 100730, China.
Background: Fibrosis of the connective tissue in the vaginal wall predominates in pelvic organ prolapse (POP), which is characterized by excessive fibroblast-to-myofibroblast differentiation and abnormal deposition of the extracellular matrix (ECM). Our study aimed to investigate the effect of ECM stiffness on vaginal fibroblasts and to explore the role of methyltransferase 3 (METTL3) in the development of POP.
Methods: Polyacrylamide hydrogels were applied to create an ECM microenvironment with variable stiffness to evaluate the effects of ECM stiffness on the proliferation, differentiation, and expression of ECM components in vaginal fibroblasts.
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