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Validation of bioanalytical method for quantification of Vitamin K2 (MK-4) in human plasma by high-performance liquid chromatography-ultraviolet.
J Adv Pharm Technol Res
October 2023
Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia.
Vitamin K can reduce warfarin's anticoagulant action, causing a variance in response among individuals taking warfarin. Vitamin K comes in two forms, namely Vitamin K1 (phylloquinone) and K2 (menaquinones). Menaquinone-4 (MK-4) is a kind of Vitamin K2 found in meat and dairy products.
View Article and Find Full Text PDFA quantitative method to measure geranylgeranyl diphosphate (GGPP) and geranylgeranyl monophosphate (GGP) in tomato (Solanum lycopersicum) fruit.
Plant Methods
June 2023
Neuchâtel Platform of Analytical Chemistry, University of Neuchâtel, 2000, Neuchâtel, Switzerland.
Background: Isoprenoids are a very large class of metabolites playing a key role in plant physiological processes such as growth, stress resistance, fruit flavor, and color. In chloroplasts and chromoplasts, the diterpene compound geranylgeranyl diphosphate (GGPP) is the metabolic precursor required for the biosynthesis of tocopherols, plastoquinones, phylloquinone, chlorophylls, and carotenoids. Despite its key role for the plant metabolism, reports on GGPP physiological concentrations in planta have been extremely scarce.
View Article and Find Full Text PDFReversed phase UPLC/APCI-MS determination of Vitamin K and menaquinone-4 in human plasma: Application to a clinical study.
J Pharm Biomed Anal
May 2020
Clinical Pharmacology Laboratory, Department of Pharmacy Practice and Science, University of Nebraska Medical Center, Omaha, NE, 68198, United States; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, United States. Electronic address:
A rapid and sensitive liquid chromatographic-tandem mass spectrometric method was developed and validated to simultaneously quantitate vitamin K (PK) and vitamin K (MK-4) concentrations in human plasma to evaluate nutritional interventions. Charcoal-stripped human plasma was used for standard and calibration preparation with vitamin E-d6 as the internal standard. Patient plasma samples were extracted using n-hexane and analytes separated using an ACE -PFP C18 column (50 × 2.
View Article and Find Full Text PDFPrediction of Peroxisomal Matrix Proteins in Plants.
Subcell Biochem
June 2019
KIIT School of Biotechnology, Campus XI, KIIT University, Bhubaneswar, 751024, India.
Our knowledge of the proteome of plant peroxisomes is far from being complete, and the functional complexity and plasticity of this cell organelle are amazingly high particularly in plants, as exemplified by the model species Arabidopsis thaliana. Plant-specific peroxisome functions that have been uncovered only recently include, for instance, the participation of peroxisomes in phylloquinone and biotin biosynthesis. Experimental proteome studies have been proved very successful in defining the proteome of Arabidopsis peroxisomes but this approach also faces significant challenges and limitations.
View Article and Find Full Text PDFDetermination of vitamins K , MK-4, and MK-7 in human serum of postmenopausal women by HPLC with fluorescence detection.
J Clin Lab Anal
June 2018
Department of Medical Chemistry and Clinical Biochemistry, Charles University, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic.
Background: New high-performance liquid chromatography (HPLC) method was developed for the determination of vitamin K and two forms of vitamin K (MK-4 and MK-7) in human serum, and the levels of vitamin K were determined in 350 samples of postmenopausal women.
Methods: Vitamin K was determined by HPLC with fluorescence detection after postcolumn zinc reduction. The detection was performed at 246 nm (excitation) and 430 nm (emission).
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