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Uptake, translocation and accumulation of the fungicide benzene kresoxim-methyl in Chinese flowering cabbage (Brassica campastris var. parachinensis) and water spinach (Ipomoea aquatica).
Environ Pollut
September 2020
Institute of Nuclear Agricultural Sciences, Key Laboratory of Nuclear Agricultural Sciences of Ministry of Agriculture and Zhejiang Province, Zhejiang University, Hangzhou, 310058, China. Electronic address:
Benzene kresoxim-methyl (BKM) is an important methoxyacrylate-based strobilurin fungicide widely used against various phytopathogenic fungi in crops. Uptake, translocation and accumulation of BKM in vegetables remain unknown. This study was designed to investigate uptake, translocation, and accumulation of C-BKM and/or its potential metabolites in Chinese flowering cabbage and water spinach.
View Article and Find Full Text PDFUptake and translocation of C-Carbamazepine in soil-plant systems.
Environ Pollut
December 2018
Institute of Nuclear Agricultural Sciences, Zhejiang University, Hangzhou, 310029, China.
Carbamazepine (CBZ) is an antiepileptic drug that is frequently detected in wastewater treatment plants, soil and plants after irrigation with treated wastewater or application of biosolids. However, little information is available on the fate and uptake of CBZ in edible vegetables. In this study, radioautographic visualization of the C distribution revealed that C-CBZ can be taken up by all three ready-to-eat vegetables.
View Article and Find Full Text PDF[Paratonsillar abscess in the patients presenting with the non-anginous form of chronic tonsillitis].
Vestn Otorinolaringol
September 2013
The present study was undertaken for the purpose of the comparative analysis of the degree of severity and inflammation-induced changes in palatine tonsils of the patients presenting with non-anginous forms of chronic tonsillitis both on the side of development of paratonsillitis and on the opposite side showing no visually visible signs of the acute inflammatory process. The secondary objective of the study was to compare pain syndrome during abscess-tonsillectomy and tonsillectomy proper, respectively. We analysed the causes behind the reduction of the total number of tonsillectomies for the treatment of chronic tonsillitis available from the accessible literature for the past 10 years.
View Article and Find Full Text PDFMapping pharmaceuticals in tissues using MALDI imaging mass spectrometry.
J Pharmacol Toxicol Methods
April 2007
Drug Metabolism and Pharmacokinetics Department, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.
During drug discovery and development stage, often the question is raised as to whether the drug can reach the site of action which helps researchers better assess the potential value of that compound as a pharmaceutical product and toxicological outcomes. High performance liquid chromatography coupled to a tandem mass spectrometer (HPLC-MS/MS) has totally replaced HPLC methods that use UV or other detectors for most drug analysis applications. However, HPLC-MS/MS approaches are not able to provide the answer to certain questions regarding the distribution of a drug in various organs or tissues from laboratory animal experiments.
View Article and Find Full Text PDFFirst discrete autoradiographic distribution of aminopeptidase N in various structures of rat brain and spinal cord using the selective iodinated inhibitor [125I]RB 129.
Neuroscience
December 2001
Département de Pharmacochimie Moléculaire et Structurale, INSERM U266, CNRS UMR 8600, UFR des Sciences Pharmaceutiques et Biologiques, Paris, France.
The selective and potent aminopeptidase N inhibitor [125I]RB 129 has been used for the radioautographic localization of this enzyme in rat brain, spinal cord and intestine. Brain microvessels and intestine brush-border cells were shown to present a high concentration of aminopeptidase N. Moreover, a labeling of various brain structures was observed.
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