The purpose of this investigation was to compare the wear rates of posterior composite resin restorations in primary versus permanent teeth. Based on theories of composite wear in primary molars, as well as on empirical observations, we hypothesized that wear would be greater in permanent tooth restorations. In Part I of the study, quantitative wear data from four different clinical trials (three permanent tooth studies and one primary tooth study) were compared. The same posterior composite restorative material was investigated in each of the four studies. In Part II of the study, quantitative wear data were drawn from a single clinical trial wherein the same experimental posterior composite material was placed in primary and permanent molars in the same children. In Part II, the baseline sample size included posterior composite restorations placed in 92 primary and 95 permanent molars in all children (ages 7-10). Quantitative wear data were obtained by the cast assessment method at baseline, six, 12, and 24 months. The 24-month sample size was based on 48 available primary molar restorations and 89 permanent molar restorations. The loss of primary restorations was due almost exclusively to natural exfoliations. Findings in Part I revealed no significant difference in the wear of primary versus permanent molar restorations. In Part II, wear findings for primary molar versus permanent teeth, respectively, were as follows (in micrometers): 47 versus 49 at six months; 86 versus 80 at 12 months; and 133 versus 131 at 24 months. With a Wilcoxon two-sample test and an alpha level of 0.05, there were no significant differences at any recall for the wear rate of primary versus permanent restorations. These results differ sharply from findings reported by others.
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http://dx.doi.org/10.1177/00220345880670011401 | DOI Listing |
Dermatol Ther (Heidelb)
January 2025
Department of Dermatology, University of Tsukuba, Tsukuba, Japan.
Introduction: Patients with moderate-to-severe atopic dermatitis (AD), a body surface area (BSA) of ≤ 40%, and an itch numerical rating scale (NRS) score of ≥ 7 ("BARI itch dominant") have been characterized as an important group to consider for the oral janus kinase (JAK) 1/2 inhibitor baricitinib (BARI). Herein we aim to evaluate quality of life (QoL) and functioning outcomes in adult patients with BSA ≤ 40% and itch NRS ≥ 7 at baseline (BL) who received BARI 4 mg in the topical corticosteroid (TCS) combination trial BREEZE-AD7.
Materials: BREEZE-AD7 was a randomized, double-blind, placebo-controlled, parallel-group outpatient study involving adult patients with moderate-to-severe AD who received once-daily placebo or 2-mg or 4-mg BARI in combination with TCS for 16 weeks.
BMC Oral Health
January 2025
Faculty of dentistry, Ain Shams University, Cairo, Egypt.
Objective: The purpose of this study was to evaluate the effect of different preparation depths (0, 2 and 4 mm) of different restoration designs (classic endocrown design versus overlay design) on marginal adaptation of restorations fabricated of two different restorative materials (lithium disilicate and PEEK).
Materials And Methods: Sixty mandibular natural molars were collected as abutments for the restorations of this study, and grouped in three main groups of different cavity depths (0, 2 and 4). Each group was divided into two subgroups according to material of fabrication to (L) for lithium disilicate (IPS emax CAD, Ivoclar vivadent, Switzarland) and (P) for PEEK (Bio-hpp, Bredent, Germany).
EClinicalMedicine
February 2025
Department of Neurosurgery, King's College Hospital Foundation Trust, London, UK.
Background: Supratentorial function-eloquent brain tumour surgeries challenge the balance between maximal tumour resection and preservation of neurological function. This study aims to evaluate the efficacy of preoperative and intraoperative mapping techniques on resection outcomes and post-operative deficits.
Methods: This systematic review and meta-analysis examined literature up to March 2023, sourced from PubMed, Embase, and Medline.
Ann Thorac Surg
January 2025
Department of Cardiovascular and Thoracic Surgery, West Virginia University, Morgantown, WV.
Background: As percutaneous therapeutic options expand, the optimal management of severe aortic stenosis (AS) and concomitant coronary artery disease (CAD) is being questioned between coronary artery bypass grafting and surgical aortic valve replacement (CABG+SAVR) versus percutaneous coronary intervention and transcatheter aortic valve replacement (PCI+TAVR). We sought to compare perioperative and longitudinal risk-adjusted outcomes between patients undergoing CABG+SAVR versus PCI+TAVR.
Methods: Using the United States Centers for Medicare and Medicaid Services inpatient claims database, we evaluated all patient age 65 and older with AS and CAD undergoing CABG+SAVR or PCI+TAVR (2018-2022).
J Am Acad Dermatol
January 2025
Sorbonne Université, Faculté de médecine, AP-HP, Service de Dermatologie et Allergologie, Hôpital Tenon, Paris, France; Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses-Paris (Cimi-Paris), INSERM U1135, Paris, France. Electronic address:
Background: Cutaneous Lupus Erythematosus (CLE) is associated with unpredictable flares and may induce permanent damage. There is currently no biomarker routinely available in CLE.
Objective: To evaluate the performance of IFN-α biological activity as biomarker of CLE activity and risk of flare.
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