AI Article Synopsis
- - The study found that giving glucocorticoids (GCs) orally significantly boosts the activity of superoxide dismutase (SOD) in red blood cells and increases nucleic acid levels (DNA and RNA) in the liver and kidneys of mice exposed to radiation.
- - GCs also reduced malondialdehyde (MDA) levels in the serum and liver, suggesting a decrease in oxidative stress.
- - The findings indicate that GCs help protect nucleic acids and have anti-radiation effects, likely due to their ability to reduce lipid peroxidation.
Article Abstract
The results showed that oral administration of GCs could markedly increase the activity of SOD in red blood cells as well as the contents of nucleic acid (DNA and RNA) in liver and kidney, decrease the contents of MDA in serum, markedly increase the activity of SOD in red blood cells as well as the contents of nucleic acid in the spleen of mice radio-induced by 60Co, and also lower the contents of MDA in liver. The results suggest that the protective effect of GCs on nucleic acid and antiradiative action may be related to its antilipid peroxidation.
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