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Comparative Transcriptome Analyses Reveal the Mechanisms Underlying Waterlogging Tolerance in Barley.
Plants (Basel)
December 2024
Key Laboratory of Plant Functional Genomics of the Ministry of Education, Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding, Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops, Joint International Research Laboratory of Agriculture and Agri-Product Safetyof Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.
Waterlogging is becoming a global issue, affecting crop growth and yield in low-lying rainfed areas. A DH line, TamF169, showing superior waterlogging tolerance, and its waterlogging-sensitive parent, Franklin, were used to conduct transcriptome analyses. The results showed that 2209 and 2578 differentially expressed genes (DEGs) in Franklin and 1997 and 1709 DEGs in TamF169 were detected by comparing gene expression levels under control and waterlogging after 4 and 8 days, respectively, with 392 and 257 DEGs being specific to TamF169 after 4 and 8 days under waterlogging, respectively.
View Article and Find Full Text PDFAnti-CD4 monoclonal antibody prevents chronic graft-versus-host disease in mice by inducing immune tolerance of CD8 T cells and alleviating thymus injury.
Front Immunol
January 2025
Department of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
Background: Chronic graft-versus-host disease (cGVHD) manifests with characteristics of autoimmune disease with organs attacked by pathogenic helper T cells. Recent studies have highlighted the role of T cells in cGVHD pathogenesis. Due to limited understanding of underlying mechanisms, preventing cGVHD after allogenic hematopoietic cell transplantation (HCT) has become a major challenge.
View Article and Find Full Text PDFExploration of key genes and pathways in response to submergence stress in red clover (Trifolium pratense L.) by WGCNA.
BMC Plant Biol
January 2025
College of Animal Science and Technology, Southwest University, Chongqing, China.
Background: Submergence stress is a prevalent abiotic stress affecting plant growth and development and can restrict plant cultivation in areas prone to flooding. Research on plant submergence stress tolerance has been essential in managing plant production under excessive rainfall. Red clover (Trifolium pratense L.
View Article and Find Full Text PDFObesity and insulinopenic type 2 diabetes differentially impact, bone phenotype, bone marrow adipose tissue, and serum levels of the cathelicidin-related antimicrobial peptide in mice.
Bone
December 2024
Marrow Adiposity and Bone Lab, MABLab-ULR4490, Univ. Littoral Côte d'Opale F-62200 Boulogne-sur-Mer, Univ. Lille F-59000 Lille, CHU Lille, F-59000 Lille, France. Electronic address:
Article Synopsis
- Obesity can lead to systemic inflammation and insulin resistance, increasing the risk of type 2 diabetes (T2D) and negatively impacting bone health, with unclear differences in effects between obesity and T2D.
- The study aimed to investigate how hyperinsulinemic obesity and insulinopenic T2D affect bone structure and bone marrow adipose tissue (BMAT), while also exploring the relationship with CRAMP expression and levels.
- Mice fed a high-fat diet exhibited significant weight gain and bone deterioration, while those with insulinopenic T2D showed severe glucose intolerance and less BMAT expansion, indicating differing impacts on bone health between the conditions.
Direct and indirect RANK and CD40 signaling regulate the maintenance of thymic epithelial cell frequency and properties in the adult thymus.
Front Immunol
December 2024
Laboratory for Immune Homeostasis, RIKEN Center of Integrative Medical Sciences, Yokohama, Japan.
Medullary thymic epithelial cells (mTECs) play a crucial role in suppressing the onset of autoimmunity by eliminating autoreactive T cells and promoting the development of regulatory T cells in the thymus. Although mTECs undergo turnover in adults, the molecular mechanisms behind this process remain unclear. This study describes the direct and indirect roles of receptor activator of NF-κB (RANK) and CD40 signaling in TECs in the adult thymus.
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