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Target Discovery Driven by Chemical Biology and Computational Biology.
Chem Rec
January 2025
Institute of Radiation Medicine, Peking Union Medical College & Chinese Academy of Medical Sciences, Tianjin, 300192, China.
Target identification is crucial for drug screening and development because it can reveal the mechanism of drug action and ensure the reliability and accuracy of the results. Chemical biology, an interdisciplinary field combining chemistry and biology, can assist in this process by studying the interactions between active molecular compounds and proteins and their physiological effects. It can also help predict potential drug targets or candidates, develop new biomarker assays and diagnostic reagents, and evaluate the selectivity and range of active compounds to reduce the risk of off-target effects.
View Article and Find Full Text PDFAcute Osmotic and pH Shock to Bioluminescent Bacteria Is Reversible in Terms of Luminescence Response.
Luminescence
January 2025
Department of Biomedical Science, Acharya Narendra Dev College, University of Delhi, New Delhi, India.
Bioluminescence inhibition (BLI) measurements in bioluminescent bacteria (BB) is perceived as a potential qualitative and quantitative indicator of hazardous materials. Acute but minor fluctuations in osmolarity and pH do not affect the living systems significantly. However, significant BLI is observed from marine BB due to acute osmolarity or pH changes that may affect the bioassay sensitivity.
View Article and Find Full Text PDFSolar Evaporator with Dual Gradient Heating Effect for Sustained and Efficient Desalination.
Small
January 2025
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.
Solar desalination shows promise in tackling freshwater shortages, but challenges arise from the trade-off between water transportation and heat supply, affecting evaporators' efficiency and salt resistance. Additionally, intermittent nature of solar radiation significantly diminishes overall evaporative performance. This study presents dual-gradient heating solar evaporator for efficient desalination.
View Article and Find Full Text PDFEffect of Dendrobium Officinale on Radioactive Oral Mucositis of Nasopharyngeal Carcinoma and Changes of Oral Microecology.
Integr Cancer Ther
January 2025
Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
Objective: To observe the clinical efficacy of Dendrobium officinale in the treatment of radiotherapy-induced oral mucositis in nasopharyngeal carcinoma patients, and to explore its regulating effect on immune function and oral microbiota by comparing immune-related factors and oral microbiota before and after the intervention.
Methods: We conducted a randomized double-blinded controlled trial in Zhejiang Cancer Hospital. Sixty patients with nasopharyngeal cancer combined with radiotherapy-induced oral mucositis were randomly divided into a study group and control group, with 30 cases in each group The study group used compound vitamin B12 solution and Dendrobium tea drink, and the control group simply used compound vitamin B12 solution rinse.
CD137 agonism enhances anti-PD1 induced activation of expanded CD8 T cell clones in a neoadjuvant pancreatic cancer clinical trial.
iScience
January 2025
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Successful pancreatic ductal adenocarcinoma (PDAC) immunotherapy requires therapeutic combinations that induce quality T cells. Tumor microenvironment (TME) analysis following therapeutic interventions can identify response mechanisms, informing design of effective combinations. We provide a reference single-cell dataset from tumor-infiltrating leukocytes (TILs) from a human neoadjuvant clinical trial comparing the granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting allogeneic PDAC vaccine GVAX alone, in combination with anti-PD1 or with both anti-PD1 and CD137 agonist.
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