A prospective, triple-blind study was undertaken to determine whether antiheart antibody or a rise in titer to a virus occurred in patients after intrapericardial surgery and, if so, whether either was related to clinical evidence of the postpericardiotomy syndrome. In 257 patients, AHA in high titer appeared in 62 (24%), all of whom had the syndrome. None of the 102 patients with no AHA had the syndrome. In 137 subjects, a rise in titer to one or more viral agents occurred in 21 of 31 (68%) of those with AHA and PPS. This study suggests that an immunologic response and viral illness are related to PPS.

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0022-3476(75)80122-3DOI Listing

Publication Analysis

Top Keywords

postpericardiotomy syndrome
8
rise titer
8
patients aha
8
immunologic virologic
4
virologic studies
4
studies postpericardiotomy
4
syndrome
4
syndrome prospective
4
prospective triple-blind
4
triple-blind study
4

Similar Publications

Purpose Of Review: This review aims to evaluate current diagnostic and therapeutic strategies for postpericardiotomy syndrome (PPS), with a focus on the evolving role of multimodality imaging, including echocardiography, cardiac computed tomography (CCT), and cardiac magnetic resonance imaging (CMR). The review also explores the potential benefits of advanced imaging in improving the accuracy and management of PPS.

Recent Findings: PPS, a common complication following cardiac surgery, presents with pleuritic chest pain, fever, and pericardial or pleural effusion.

View Article and Find Full Text PDF

We appreciate the concerns raised by Ali. As well recognized, Post-Pericardiotomy Syndrome (PPS) has been a very difficult syndrome to classify and understand in part relating to variable methodologic approaches in the literature, and any attempts to clarify and unify methodology will only aid in better understanding this entity. Below is a point-by-point response to concerns raised.

View Article and Find Full Text PDF
Article Synopsis
  • The article critiques Hyberg et al.'s study on early ECG changes predicting postoperative complications after atrial septal defect repair, expressing appreciation for their insights.
  • The author raises concerns about the methodology, particularly the use of ESC criteria without pediatric-specific considerations and the narrow focus on certain ECG indicators.
  • Suggestions for future research include incorporating standardized timing for ECGs and addressing independent risk factors for Post-Pericardiotomy Syndrome to enhance diagnostic strategies.
View Article and Find Full Text PDF

Introduction: The systemic inflammatory response syndrome during the perioperative period of cardiac surgery can lead to serious postoperative complications and significantly increase the hospital mortality rate. Colchicine, a widely used traditional anti-inflammatory drug, has good clinical value in cardiovascular anti-inflammatory therapy. Our preliminary single-centre study had confirmed the protective value of colchicine in patients undergoing cardiac surgery with cardiopulmonary bypass.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!