Using the subcellular fractionation technique the fine structure of the isolated nerve endings (synaptosomes) from the hemispheres and brain stem of the 1-day old and adult rat was examined. In the synaptosomal fractions of the brain of 1-day old rats we observed a new type of nerve endings containing predominantly large agranular vesicles about 1,000 A in diameter. After incubation with alpha-methylnoradrenaline or 5-hydroxydopamine these vesicles remained agranular. It is assumed that the new type of large vesicles represent developing synaptic vesicles.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1748-1716.1975.tb05899.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Myelination and excitation-inhibition balance synergistically shape structure-function coupling across the human cortex.
Nat Commun
September 2023
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Recent work has demonstrated that the relationship between structural and functional connectivity varies regionally across the human brain, with reduced coupling emerging along the sensory-association cortical hierarchy. The biological underpinnings driving this expression, however, remain largely unknown. Here, we postulate that intracortical myelination and excitation-inhibition (EI) balance mediate the heterogeneous expression of structure-function coupling (SFC) and its temporal variance across the cortical hierarchy.
View Article and Find Full Text PDFRepresentations of tactile object location in the retrosplenial cortex.
Curr Biol
November 2023
Institute of Basic Medical Sciences, Section of Physiology, University of Oslo, Sognsvannsveien 9, 0372 Oslo, Norway. Electronic address:
How animals use tactile sensation to detect important objects and remember their location in a world-based coordinate system is unclear. Here, we hypothesized that the retrosplenial cortex (RSC), a key network for contextual memory and spatial navigation, represents the location of objects based on tactile sensation. We studied mice palpating objects with their whiskers while navigating in a tactile virtual reality in darkness.
View Article and Find Full Text PDFClodronate Liposome-Mediated Phagocytic Hemocyte Depletion Affects the Regeneration of the Cephalic Tentacle of the Invasive Snail, .
Biology (Basel)
July 2023
Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
After amputation, granular hemocytes infiltrate the blastema of regenerating cephalic tentacles of the freshwater snail . Here, the circulating phagocytic hemocytes were chemically depleted by injecting the snails with clodronate liposomes, and the effects on the cephalic tentacle regeneration onset and on -Hemocyanin, -transglutaminase (-TG) and -Allograft Inflammatory Factor-1 (-AIF-1) gene expressions were investigated. Flow cytometry analysis demonstrated that clodronate liposomes targeted large circulating hemocytes, resulting in a transient decrease in their number.
View Article and Find Full Text PDFAssociations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex.
Acta Neuropathol
April 2023
Department of Translational Research in Psychiatry, Max-Planck Institute of Psychiatry, Munich, Germany.
Identification and characterisation of novel targets for treatment is a priority in the field of psychiatry. FKBP5 is a gene with decades of evidence suggesting its pathogenic role in a subset of psychiatric patients, with potential to be leveraged as a therapeutic target for these individuals. While it is widely reported that FKBP5/FKBP51 mRNA/protein (FKBP5/1) expression is impacted by psychiatric disease state, risk genotype and age, it is not known in which cell types and sub-anatomical areas of the human brain this occurs.
View Article and Find Full Text PDFA Rare Case of Blastic Plasmacytoid Dendritic Cell Neoplasm in a Child Mimicking Lymphoma/Leukemia Cutis.
Dermatopathology (Basel)
September 2022
Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare tumor that affects elderly individuals and presents a poor prognosis. Skin is the most common site of involvement, accounting for 89% of the cases. Extracutaneous organs, especially bone marrow, lymph nodes, and peripheral blood, can be involved at the time of diagnosis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!