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The Formyl Peptid Receptor Ligand Ac2-26 Improves the Integrity of the Blood-Brain Barrier in the Course of Pneumococcal Meningitis.
Cells
December 2024
Institute of Anatomy, Rostock University Medical Center, Rostock, Gertrudenstraße 9, 18057 Rostock, Germany.
Background: The brain is protected from invading pathogens by the blood-brain barrier (BBB) and the innate immune system. Pattern recognition receptors play a crucial role in detecting bacteria and initiating the innate immune response. Among these are G-protein-coupled formyl peptide receptors (FPR), which are expressed by immune cells in the central nervous system.
View Article and Find Full Text PDFQingfei Yin alleviates Streptococcus pneumoniae pneumonia by promoting complete autophagy to suppress necroptosis.
Phytomedicine
November 2024
Pediatric Respiratory Medicine Department, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, PR China. Electronic address:
Background: Bacterial pneumonia is most prevalent among all pneumonia types, with Streptococcus pneumoniae being the main pathogen. Qingfei Yin (QFY) is a traditional Chinese medicine formula used in the clinical treatment of bacterial pneumonia. Previous studies have confirmed the multi-target and -effect characteristics of QFY in treating S.
View Article and Find Full Text PDFLeukocyte kinetics and bacterial clearance during pneumonia and contributions of ICAM-1.
Am J Physiol Lung Cell Mol Physiol
January 2025
Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
is a leading cause of community-acquired pneumonia. Intercellular adhesion molecule-1 (ICAM-1) is an adhesion molecule that is highly expressed on the pulmonary capillary endothelium, alveolar epithelium, and other cell types within the lung. ICAM-1 plays important roles in leukocyte adhesion, migration, and motility.
View Article and Find Full Text PDFA severe case of reactive infectious mucocutaneous eruption associated with two possible triggers: Coronavirus and group A streptococcus.
Pediatr Dermatol
September 2024
Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Reactive infectious mucocutaneous eruption (RIME) is a newly defined condition characterized by mucocutaneous blistering secondary to upper respiratory infections and encompasses Mycoplasma pneumoniae-induced rash and mucositis, broadening the disease spectrum to include various infectious etiologies. We present a severe RIME case involving a 5-year-old female with concurrent coronavirus NL63 and group A streptococcus infections. Diagnosis complexity stemmed from overlapping clinical features with other severe mucocutaneous eruptions such as Stevens-Johnson syndrome/toxic epidermal necrolysis/drug-induced necrolysis.
View Article and Find Full Text PDFIndividual Atg8 paralogs exhibit unique properties in -induced hierarchical autophagy.
Autophagy
November 2024
Department of Bacteriology I, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan.
Individual Atg8 (autophagy related 8) paralogs, comprising MAP1LC3A/LC3A, LC3B, LC3C, GABARAP, GABARAPL1 and GABARAPL2/GATE16, play a crucial role in canonical macroautophagy/autophagy. However, their functions remain unclear owing to functional redundancy. In a previous study, we reported that intracellular triggers hierarchical autophagy in response to bacterial infection.
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