We report a case of a hypophyseal granular cell tumour (GCT) presenting with visual failure and hyperprolactinaemia (serum prolactin level, 274 ng/ml; normal, < 10). Magnetic resonance images demonstrated an intrasellar mass with anterosuperior extension. As the patient had chronic renal failure (CRF) and hyperprolactinaemia is frequent in CRF patients, a firm preoperative diagnosis of prolactinoma could not be made. Transsphenoidal removal of the tumour resulted in improvement of both vision and serum prolactin. Histopathological analysis of the surgical specimen revealed GCT. A cell kinetic study, the first such report for this type of tumour, revealed a relatively high Ki-67 staining index of 3.2%. On electron microscopy, numerous intracytoplasmic granules with various electron densities were demonstrated. Moreover, cell-processes extending from the granule-rich cytoplasm contained intracytoplasmic filaments but few granules, suggesting that the filament-rich cells, which are occasionally seen in GCT tissues, are essentially identical to the granule-rich cells in origin.
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http://dx.doi.org/10.1080/02688699745790 | DOI Listing |
Int J Surg Case Rep
November 2024
Department of Pathology, Chang Gung Memorial Hospital, Linkou Center, Taoyuan City, Taiwan.
Introduction: Pituitary spindle cell oncocytoma (PSCO) is a seldom-encountered type of pituitary neoplasm with distinctive histological features. It was first described as a distinct entity by Roncaroli et al. in 2002.
View Article and Find Full Text PDFCureus
August 2024
Neurosurgery, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, IND.
Pilomyxoid astrocytoma (PMA) is a subtype of pilocytic astrocytoma (PA). PMA tends to exhibit a more aggressive course compared to PA. We present a case of a two-year-old male with a PMA in the suprasellar region who presented with developmental regression, loss of previously attained milestones such as the ability to hold his neck, walk, and talk, along with hypotonia in all four limbs.
View Article and Find Full Text PDFNeurol India
May 2024
Department of Pathophysiology and Transplantation, Unit of Neurosurgery, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Am J Clin Pathol
November 2024
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, US.
Objectives: The incidence of pituitary neuroendocrine tumors has been reported high at autopsy. This study aimed to detect many tumors in both anterior and posterior lobes to prove tumor histogenesis.
Methods: In total, 150 pituitary glands were studied from the University of Kansas Medical Center from 1995 to 2000.
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