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Diagnostic challenges associated with adrenocortical neoplasms arising from adreno-hepatic fusion: a case report of two patients and a literature review.
Gland Surg
December 2024
Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea.
Background: A right adrenal gland may present in the form of adreno-hepatic fusion (AHF), in which the adrenal cells are interspersed among the hepatocytes without septation. This rare, naturally-occurring phenomenon may be associated with preoperative misdiagnosis. We present two cases of adrenal tumor in patients with AHF that were misdiagnosed, despite thorough preoperative work-ups.
View Article and Find Full Text PDFPET-CT-based host metabolic (PETMet) features are associated with pathologic response in gastroesophageal adenocarcinoma.
Eur J Surg Oncol
January 2025
Division of Surgical Oncology, Department of Surgery, Northwell Health, New Hyde Park, NY, USA; Gastric and Mixed Tumor Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:
Background: F-FDG PET-CT-based host metabolic (PETMet) profiling of non-tumor tissue is a novel approach to incorporate the patient-specific response to cancer into clinical algorithms.
Materials And Methods: A prospectively maintained institutional database of gastroesophageal cancer patients was queried for pretreatment PET-CTs, demographics, and clinicopathologic variables. F-FDG PET avidity was measured in 9 non-tumor tissue types (liver, spleen, 4 muscles, 3 fat locations).
A 47-year-old woman, a diagnosed case of syndrome of inappropriate secretion of antidiuretic hormone, underwent 18F-FDG PET/CT to detect occult malignancy for suspected paraneoplastic etiology. Abnormal FDG uptake was noted in the right lower chest region, which was correlated on corresponding CT images to be colonic activity interposed between the liver and elevated diaphragm, also known as Chilaiditi sign. Even though rare, Chilaiditi sign should be considered as a differential diagnosis of hypermetabolic activity in the right lower chest region on 18F-FDG PET/CT scan that is done to look for occult tumor as shown in this case.
View Article and Find Full Text PDFA novel molecular classification system based on the molecular feature score identifies patients sensitive to immune therapy and target therapy.
Front Immunol
December 2024
Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Background: Hepatocellular carcinoma (HCC) is heterogeneous and refractory with multidimensional features. This study aims to investigate its molecular classifications based on multidimensional molecular features scores (FSs) and support classification-guided precision medicine.
Methods: Data of bulk RNA sequencing, single nucleotide variation, and single-cell RNA sequencing were collected.
The role of PET/CT scan in addressing autoinflammatory diseases; A case report of a young man presenting with fever, splenomegaly and exanthem.
Hell J Nucl Med
December 2024
3rd Internal Medicine Department and Liver Outpatient Unit, Evangelismos General Hospital, Athens, Greece.
Article Synopsis
- Adult-onset Still's disease (AOSD) is a rare inflammatory condition that includes symptoms like daily fevers, joint pain, skin rashes, and spleen enlargement, often requiring tests to rule out blood cancers.
- A case study of a 38-year-old man revealed symptoms such as fatigue, high fever, night sweats, and skin rashes, leading to extensive testing, including CT and PET/CT scans that showed enlarged lymph nodes and high metabolic activity in his spleen and bone marrow.
- Ultimately, biopsies of the lymph node and bone marrow showed signs of hyperreactivity but no cancer, confirming AOSD as a diagnosis of exclusion, particularly when high ferritin levels and systemic symptoms are present
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