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The Association of Dietary Polyamines with Mortality and the Risk of Cardiovascular Disease: A Prospective Study in UK Biobank.
Nutrients
December 2024
Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Background: Polyamines, including spermidine (SPD), spermine (SPM) and putrescine (PUT), are essential for cellular physiology and various cellular processes. This study aimed to examine the associations of dietary polyamines intake and all-cause mortality and incident cardiovascular disease (CVD).
Methods: This prospective cohort study included 184,732 participants without CVD at baseline from the UK Biobank who had completed at least one dietary questionnaire.
Aminophylline at clinically relevant concentrations affects inward rectifier potassium current in healthy porcine and failing human cardiomyocytes in a similar manner.
Biomed Pharmacother
December 2024
ICRC, St. Anne's University Hospital, Pekařská 53, Brno 602 00, Czech Republic; 1st Department of Internal Medicine, Cardio-Angiology, Faculty of Medicine, Masaryk University, Pekařská 53, Brno 602 00, Czech Republic.
Article Synopsis
- - Aminophylline, a medication often used for severe asthma, can cause arrhythmias, but the exact reasons are not clear
- - In research, aminophylline significantly inhibited the inward rectifier potassium current in both healthy pig heart cells and failing human heart cells at different concentrations
- - The study found that aminophylline prolonged action potential duration in porcine heart cells, indicating its potential role in causing arrhythmias, suggesting further exploration of its effects on other ionic currents is necessary
Development of a diagnostic and drug evaluation system for acute inflammation using a novel [Zr]DTPA-sorbitol probe.
J Mater Chem B
January 2025
Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea.
Non-invasive imaging techniques employing biomarkers with high selectivity for inflammation are essential not only for the early diagnosis and prevention of chronic inflammatory diseases but also for guiding appropriate drug therapy and enabling real-time evaluation of anti-inflammatory drug efficacy. In this study, we conjugated radioactive zirconium to sorbitol, a compound that can selectively target inflammation, and evaluated its inflammation-specific uptake and potential for assessing anti-inflammatory treatment efficacy in a mouse inflammation model. Pharmacokinetic analysis demonstrated that radiolabeled sorbitol achieved maximal uptake in inflamed tissues within 1 h.
View Article and Find Full Text PDFCharacterization of two Campylobacter jejuni phages and evaluation of their antibacterial efficacy with EDTA.
Arch Virol
November 2024
Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
Campylobacter jejuni is a leading cause of foodborne illness worldwide. The application of bacteriophages offers a promising approach to specifically target and reduce C. jejuni contamination in food products.
View Article and Find Full Text PDFSalbutamol attenuates arrhythmogenic effect of aminophylline in a hPSC-derived cardiac model.
Sci Rep
November 2024
Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
The combination of aminophylline and salbutamol is frequently used in clinical practice in the treatment of obstructive lung diseases. While the side effects (including arrhythmias) of the individual bronchodilator drugs were well described previously, the side effects of combined treatment are almost unknown. We aimed to study the arrhythmogenic potential of combined aminophylline and salbutamol treatment in vitro.
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