Determination of four selective serotonin reuptake inhibitors by capillary isotachophoresis.

Electrophoresis

Department of Analytical Chemistry, Faculty of Chemical Technology, Slovak Technical University, Bratislava.

Published: August 2000

AI Article Synopsis

  • Determined an optimal electrolyte system for isotachophoresis (ITP) with conductivity detection focusing on four antidepressants: citalopram, fluoxetine, fluvoxamine, and sertraline.
  • Utilized specific analysis conditions to effectively detect these selective serotonin re-uptake inhibitors in antidepressant formulations.
  • Demonstrated that capillary ITP with conductivity detection is an efficient and rapid method for analyzing these medications.

Article Abstract

We determined an optimal electrolyte system for isotachophoresis (ITP) with conductivity detection of citalopram, fluoxetine, fluvoxamine and sertraline. The analysis conditions were applied to the determination of these selective serotonin re-uptake inhibitors in antidepressant drugs. It is shown that capillary ITP with conductivity detection is a simple and quick method for the determination of citalopram, fluoxetine, fluvoxamine and sertraline in drugs.

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Source
http://dx.doi.org/10.1002/1522-2683(20000801)21:14<2839::AID-ELPS2839>3.0.CO;2-JDOI Listing

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