AI Article Synopsis
- The study involved three groups of male Wistar rats, each consisting of 10 rats, with one group as a control and two groups treated with different doses of magnesium sulfate (100 mg/kg and 200 mg/kg).
- The rats were observed over 9 days for behavior in an open field and their ability to learn active avoidance in a shuttle-box.
- Results showed that magnesium sulfate reduced learning ability and emotivity scores in all groups, while only the higher dose increased spontaneous motility.
Article Abstract
The study was performed on three groups, each including 10 male Wistar rats, weighing 110-130 g: group 1, the control group; group 2, animals treated with magnesium sulfate in a dose of 100 mg/kg body/day i.m.; group 3, animals treated with double dose of magnesium sulfate (200 mg/kg body/day i.m.). All animals were tested for emotivity and spontaneous motility in the open field, as well as for their capacity of acquiring active avoidance conditioned reflexes in the shuttle-box, for 9 days. Magnesium sulfate decreased significantly the learning ability, decreased emotivity scores regardless of the administered dose, and increased significantly spontaneous motility scores only in the double dose treated group.
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