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The weakly ionized plasma in the Earth's ionosphere is controlled by a complex interplay between solar and magnetospheric inputs from above, atmospheric processes from below, and plasma electrodynamics from within. This interaction results in ionosphere structuring and variability that pose major challenges for accurate ionosphere prediction for global navigation satellite system (GNSS) related applications and space weather research. The ionospheric structuring and variability are often probed using the total electron content (TEC) and its relative perturbations (dTEC).
View Article and Find Full Text PDFTrypsin Digestion Conditions of Human Plasma for Observation of Peptides and Proteins from Tandem Mass Spectrometry.
ACS Omega
October 2024
Research Analytical Biochemistry Laboratory, Department of Chemistry and Biology, Toronto Metropolitan University, Toronto M5B 2K3, Canada.
Previous meta-analysis indicated that plasma or serum proteome groups using various experimental conditions detected different peptides from the same plasma proteins, which is strong evidence for the veracity of blood fluid LC-ESI-MS/MS but also evidences that the trypsin digestion step is a key source of variation in plasma proteomics. Agreement between different digestion conditions and MS/MS algorithms may serve as an independent confirmation of the validity of the LC-ESI-MS/MS analysis of plasma peptides. Plasma contains a high percentage of albumin held together by multiple disulfide bonds; hence, reduction and/or alkylation may greatly enhance the digestion efficiency of albumin.
View Article and Find Full Text PDFHER4 is a high-affinity dimerization partner for all EGFR/HER/ErbB family proteins.
Protein Sci
October 2024
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, USA.
Article Synopsis
- Human epidermal growth factor receptors (HER), including HER4, are important proteins that influence cell growth and survival, but HER4 is less studied due to its low expression in later development stages.
- Recent research indicates that HER4 may contribute to cancer metastasis by affecting cell movement, but its exact function in tumor development is still unclear.
- Using a technique called pulsed interleaved excitation fluorescence cross-correlation spectroscopy (PIE-FCCS), the study found that HER4 interacts with all HER receptors in live cells and this interaction increases in the presence of a specific ligand, making HER4 a key partner for dimerization among the HER proteins.
Acute Vigorous Exercise Decreases Subsequent Nonexercise Physical Activity and Body Temperature Linked to Weight Gain.
Med Sci Sports Exerc
October 2024
Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, JAPAN.
Purpose: Exercise benefits the body and mind, but its weight loss effect is less than generally expected. Although this phenomenon is likely due to an exercise intensity-dependent decrease in non-exercise physical activity (NEPA), resulting in a decrease in non-exercise activity thermogenesis, the underlying mechanisms and effects of exercise intensity remain unknown. Here we show that acute vigorous exercise decreases subsequent NEPA and body temperature (BT) in association with body weight gain.
View Article and Find Full Text PDFDetection and quantification of Na,K-ATPase dimers in the plasma membrane of living cells by FRET-FCS.
Biochim Biophys Acta Gen Subj
July 2024
Science for Life Laboratory, Department of Applied Physics, KTH Royal Institute of Technology, Box 1031, 171 21 Solna, Sweden; Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Box 1031, 171 21 Solna, Sweden.
The sodium potassium pump, Na,K-ATPase (NKA), is an integral plasma membrane protein, expressed in all eukaryotic cells. It is responsible for maintaining the transmembrane Na gradient and is the major determinant of the membrane potential. Self-interaction and oligomerization of NKA in cell membranes has been proposed and discussed but is still an open question.
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