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Cardiotoxicity of breast cancer drug treatments.
Transl Oncol
March 2025
School of Veterinary Medicine and Science, Faculty of Medicine and Health Sciences University of Nottingham, UK; Biodiscovery Institute, Faculty of Medicine and Health Sciences, University of Nottingham, UK. Electronic address:
Breast cancer (BC) is a leading cause of cancer-related mortality among women worldwide. BC is regarded as a systemic disease. Consequently, the majority of BC patients undergo systemic therapy to reduce the risk of distant metastasis (DM) and associated mortality.
View Article and Find Full Text PDFSleep and the Mediterranean diet: A systematic review and meta-analysis.
Sleep Med Rev
February 2025
Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA; Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA. Electronic address:
We conducted the current systematic review and meta-analysis to critically review and synthesize available evidence regarding the association between sleep duration, sleep quality, and chronotype with the Mediterranean diet (MedDiet) among the general population using observational studies. Online databases, including PubMed, Scopus, and ISI Web of Science, were searched from the earliest available date until December 2024. We enrolled 62 studies with a total sample size of 328,493.
View Article and Find Full Text PDFPopulation-Level Risks for HIV Mortality During the COVID-19 Pandemic in the United States by Demographic Characteristics and Medicaid Access, 2020‒2021.
Am J Public Health
April 2025
Donrie Purcell is with the Satcher Health Leadership Institute, Morehouse School of Medicine (MSM), Atlanta, GA. Wayne A. Duffus is with the Department of Medicine, Division of Infectious Diseases, University of South Carolina School of Medicine, Columbia. Maisha Standifer is with the Satcher Health Leadership Institute and Department of Community Health and Preventive Medicine, MSM. Robert Mayberry is with the Department of Community Health and Preventive Medicine and the MSM Research Design and Biostatistics Core, MSM. Sonja S. Hutchins is with the Department of Community Health and Preventive Medicine, MSM.
To evaluate the impact of the COVID-19 pandemic on HIV mortality rates with a focus on demographic predictors and Medicaid access. Using Wide-Ranging Online Data for Epidemiologic Research, we conducted a descriptive study comparing HIV mortality in the United States 2 years before the COVID-19 pandemic (2018-2019) and the initial 2 years of the pandemic (2020-2021), and identifying HIV mortality factors during the pandemic. During the first 2 years of the pandemic, crude HIV death rates increased and then decreased marginally.
View Article and Find Full Text PDFCaki-1 Spheroids as a Renal Model for Studying Free Fatty Acid-Induced Lipotoxicity.
Cells
February 2025
Department of Physiology, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Lipotoxicity, resulting from the buildup of excess lipids in non-adipose tissues, is increasingly recognized as a major contributor to the progression of kidney disease, highlighting the need for alternative models to assess its effects on renal cells. The main aim of this study was to investigate the usefulness of Caki-1, a human proximal tubule (PT) and renal cell carcinoma (RCC) representative cell line, as a 3D model system for studying free fatty acid-induced PT lipotoxicity. Caki-1 spheroids were generated and maintained on ultra-low attachment plates and characterized regarding time-dependent morphology changes.
View Article and Find Full Text PDFPrior studies of the role of state spending on home and community-based services (HCBS) in nursing home use focused on adults over the age of 65. However, medically complex children and adults under 50 years old represent a small (about 5%) but highly vulnerable subset of nursing home patients. We measured the impact of HCBS spending on short-term and long-term nursing home stays by children and adults under 44 years old and compared the impact between Non-Hispanic White (NHW) individuals and Black, Indigenous, and People of Color (BIPOC).
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