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Billion-Scale Expansion of Functional hiPSC-Derived Cardiomyocytes in Bioreactors Through Oxygen Control and Continuous Wnt Activation.
Adv Sci (Weinh)
January 2025
iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, Oeiras, 2780901, Portugal.
Generation of upscaled quantities of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM), for therapeutic or testing applications, is both expensive and time-consuming. Herein, a scalable bioprocess for hiPSC-CM expansion in stirred-tank bioreactors (STB) is developed. By combining the continuous activation of the Wnt pathway, through perfusion of CHIR99021, within a mild hypoxia environment, the expansion of hiPSC-CM as aggregates is maximized, reaching 4 billion of pure hiPSC-CM in 2L STB.
View Article and Find Full Text PDFFacile preparation of marine carrageenan hydrogel-coated steel mesh with superhydrophilic and underwater superoleophobic performance for highly efficient oil-water separation.
Water Environ Res
January 2025
Zhejiang Key Laboratory of Petrochemical Environmental Pollution Control, Zhejiang Ocean University, Zhoushan, P. R. China.
The discharge of oil-laden wastewater from industrial processes and the frequent occurrence of oil spills pose severe threats to the ecological environment and human health. Membrane materials with special wettability have garnered attention for their ability to achieve efficient oil-water separation by leveraging the differences in wettability at the oil-water interface. These materials are characterized by their simplicity, energy efficiency, environmental friendliness, and reusability.
View Article and Find Full Text PDFChiral nematic cellulose nanocrystal films: Sucrose modulation for structural color and dynamic behavior.
Int J Biol Macromol
January 2025
Department of Chemical and Biological Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK S7N 5A9, Canada. Electronic address:
This study explores the effect of sucrose addition on the properties of chiral nematic cellulose nanocrystal (CNC) films for potential food industry applications, including biodegradable packaging and food coloring. The addition of sucrose altered the films' structural color, shifting from blue in pure CNC films to aqua blue, green, yellow-green, and red with increasing sucrose concentrations (up to 21 %). Surface analysis revealed a reduction in contact angle from 96° to 48° due to sucrose's hydrophilic nature and smoother film surfaces.
View Article and Find Full Text PDFConstruction of a red phosphorus-molybdenum dioxide electron-rich interface for efficient photocatalytic reduction of carbon dioxide.
J Colloid Interface Sci
January 2025
School of Environmental Science and Engineering, Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Sun Yat-sen University, Guangzhou 510006, China. Electronic address:
Developing efficient catalysts to enhance photoreduction carbon dioxide (CO) into hydrocarbon fuels is a great challenge. As metallic material, molybdenum dioxide (MoO) has very high conductivity and charge density, which make it a promising candidate as photocatalyst. However, its photocatalytic activity is limited by the serious charge recombination.
View Article and Find Full Text PDFFeasibility and Oncological Outcome of Patients Achieving Noninvasive Downstaging After Transurethral Resection of Bladder Tumor Plus Systemic Chemotherapy for Bladder Preservation Strategy in Muscle-Invasive Bladder Cancer.
Clin Genitourin Cancer
December 2024
Department of Urology, Mie University hospital, Tsu, Japan.
Article Synopsis
- The study aimed to assess the outcomes of bladder preservation therapy combining maximal TURBT and neoadjuvant chemotherapy in muscle-invasive bladder cancer patients.
- A total of 110 patients were treated, with 61 achieving noninvasive downstaging, allowing them to preserve their bladders.
- The findings indicated that bladder preservation therapy had comparable survival rates to radical cystectomy, but more research is necessary to confirm these results due to the retrospective nature of the study.
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