[The cellular and humoral mechanisms of the radioprotective action of prodigiozan and indometofen on long-term mouse bone marrow cultures].

Effects of prodigiosan and indometophen on the contents and proliferative activity of CFU and CFU-GM as well as GM-CSF prior to radiation were studied in long-term cultures of murine bone marrow. 24 hours and 5 days after administration of prodigiosan and indometophen, respectively, the long-term cultures were exposed to ionising radiation in a dose 2.0 Gy. Then, postradiation restoration of early hemopoietic cells-precursors was assessed. In unradiated cultures 24 hours after prodigiosan administration content of CFU, CFU-GM and GM-CSF increased. Indometophen administration induced unstable changes in the number of CFU and CFU-GM, elevation of GM-CSF within 1-14 days, stimulation of CFU proliferative activity within 24 hours, inhibition of CFU-HM proliferation in 1 and 6 days. After radiation, in prodigiosan- and indometophen-defended cultures radiation damage declined while postradiation recovery of CFU, CFU-GM and total number of myelokaryocytes was more active.