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Clinical implications of residual shunt after patent foramen ovale closure.
Minerva Cardiol Angiol
November 2024
Department of Interventional Cardiology, Sanremo Hospital, Sanremo, Imperia, Italy -
Article Synopsis
- Residual shunt (RS) after percutaneous patent foramen ovale (PFO) closure remains controversial regarding its link to subsequent ischemic events, requiring consideration of various injury mechanisms.
- Biochemical evidence suggests that successful PFO closure significantly reduces levels of molecules (like serotonin and homocysteine) associated with stroke risk, aligning the blood composition of patients post-procedure with that of healthy individuals.
- The review highlights the variability in study findings due to differences in populations, assessment methods, and follow-up duration, with recent guidelines identifying RS as a potential predictor for ischemic event recurrence, emphasizing the need for further research in this area.
Risk factors for cardiovascular diseases in patients with vitiligo: an analysis of current evidence.
Ann Med
December 2024
Chinese Medicine Department, Songnan Town Community Health Service Center, Shanghai, China.
Objective: The relationship between vitiligo and cardiovascular diseases remains controversial. This study aimed to systematically review the evidence comparing cardiovascular disease risk factors between patients with vitiligo and controls and to perform a meta-analysis of the results.
Data Sources: A comprehensive database search was performed for all studies in PubMed, EMBASE, and Cochrane Central Register databases from inception to November, 2023.
The impact of maternal vulnerability on stress biomarkers and first-trimester growth: the Rotterdam Periconceptional Cohort (Predict Study).
Hum Reprod
November 2024
Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Article Synopsis
- - The study looks at whether stress hormones in pregnant women, called maternal vulnerability, can affect their baby's growth in the first trimester.
- - Researchers found that higher levels of certain stress hormones in hair were linked to slower growth of the baby, while another substance called tryptophan was lower when stress was higher.
- - The study used data from 132 pregnant women over a year to create a risk score for how vulnerable they are to stress and how it impacts their pregnancies.
Subacute combined degeneration from nitrous oxide abuse.
Radiol Case Rep
December 2024
Department of Internal Medicine, Henry Ford Allegiance Health, Jackson, MI, USA.
Nitrous oxide is an anesthetic medication which can also be recreationally abused in the form of whippet canisters. Its prolonged abuse can interfere with Vitamin B12 metabolism and lead to its functional deficiency. We report a case of a 30-year-old male who presented with generalized weakness and was found to have subacute combined degeneration (SCD) of the spinal cord.
View Article and Find Full Text PDFBackground And Objective: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme involved in folate metabolism and one-carbon metabolism. MTHFR gene polymorphism affects enzyme activity. MTHFR gene polymorphism is closely related to many human diseases, such as cardiocerebrovascular diseases, diabetes, neural tube defects (NTDs), tumors, and so on.
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