It is now generally recognized that in order to make significant advances in accident prevention, the focus of industrial firms must shift from assessing the risks of existing production and manufacturing systems to discovering technological alternatives, i.e. from the identification of problems to the identification of solutions. Encouraging the industrial firm to perform (1) an inherent safety opportunity audit (ISOA) to identify where inherently safer technology (IST) is needed, and (2) a technology options analysis (TOA) and to identify specific inherently safer options that will advance the adoption of primary prevention strategies that will alter production systems so that there are less inherent safety risks. Experience gained from a methodology to encourage inherently safer production (ISP) in industrial firms in the Netherlands and Greece is discussed. Successful approaches require both technological and managerial changes. Firms must have the willingness, opportunity, and the capability to change. Implications for the EU Seveso, IPPC, and EMAS Directives are also discussed.
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Angew Chem Int Ed Engl
January 2025
Institute of Materials Research and Engineering, Sensor and Flexible Electronics, 2 Fusionopolis Way, 138634, SINGAPORE.
Radical covalent organic frameworks (RCOFs) have demonstrated significant potential in redox catalysis and energy conversion applications. However, the synthesis of stable RCOFs with well-defined neutral carbon radical centers is challenging due to the inherent radical instability, limited synthetic methods and characterization difficulties. Building upon the understanding of stable carbon radicals and structural modulations for preparing crystalline COFs, herein we report the synthesis of a crystalline carbon-centered RCOF through a facile post-oxidation process.
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Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, 110001, China.
The management and treatment of tumor complications pose continuous challenges due to the inherent complexity. However, the advent of drug delivery systems (DDSs) brings promising opportunities to address the tumor complications using innovative technological approaches. This review focuses on common oncological complications, including cancer thrombosis, malignant serous effusion, tumor-associated infections, cancer pain, and treatment-related complications.
View Article and Find Full Text PDFBiomed Pharmacother
January 2025
Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran.
The inherent limitations of traditional treatments for Diabetic Retinopathy (DR) have spurred the development of various nanotechnologies, offering a safer and more efficient approach to managing the disease. Nanomedicine platforms present promising advancements in the diagnosis and treatment of DR by enhancing imaging capabilities, enabling targeted and controlled drug delivery. These innovations ultimately lead to more effective and personalized treatments with fewer side effects.
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December 2024
Orthopedic Surgery, National and Kapodistrian University of Athens, Attikon Hospital, Athens, GRC.
Combat sports encompass a wide range of disciplines, each associated with distinct injury patterns and mechanisms. From karate to wrestling, athletes face varying degrees of injury risks, with common clinical presentations including head injuries, strains, sprains, fractures, and concussions. These injuries often result from dynamic movements, physical contact, and high-impact collisions inherent to combat sports.
View Article and Find Full Text PDFBrain Dev
December 2024
Department of Pediatrics and Adolescent Medicine, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
Background: Safe pediatric magnetic resonance imaging (MRI) ideally relies on non-sedative techniques, as avoiding risky sedation is inherently safer. However, in practice, sedation often becomes unavoidable, particularly for younger children or those with anxiety, to ensure motion-free, high-quality imaging. This narrative review explores the current practices and proposes strategies to enhance safety in pediatric MRI examinations.
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