Specific effect of epidermal growth factor immobilized on wound coating with soluble collagen on healing of experimental wounds.

Electron-microscopy and autoradiography of granulation tissue in wounds showed that bioactive coating with epidermal growth factor activates functional and proliferative processes in vascular cells (endotheliocytes and pericytes) and fibroblasts and increases the number of cell-to-cell contacts on days 2-3 of therapy. Pronounced activation of proliferative processes resulted in early differentiation of fibroblast cells (on days 3-4) and rapid epithelialization of the wound.