Peripheral neurotoxicity is an important side-effect of several chemotherapeutic agents. These agents may cause a usually axonal neuropathy, which may ultimately lead to severe and disabling symptoms and signs. We describe in this review the pathogenesis, clinical presentation, neurophysiologic findings, nerve biopsies and the relation between cumulative dosage/dosage per cycle and neuropathy for the cytostatic drugs for which neurotoxicity is an important side-effect: cisplatin, vincristine, paclitaxel, docetaxel and suramin. With the development of strategies to circumvent toxicities of other organs and with the use of combinations of neurotoxic agents such as cisplatin/paclitaxel, neurotoxicity is an important and dose-limiting side-effect of many treatment regimens. Detailed knowledge of the neurologic side-effects of these drugs is essential for the management of their neurotoxicity. The review concludes with a short discussion of neuroprotective agents. Although several nerve growth factors, gluthatione and ethiofos hold promise as possible neuroprotective factors, the clinical data on these drugs are still limited. New trials are needed to confirm the value of these drugs. If neurotoxicity could indeed be prevented or delayed, this may lead to more effective treatment regimens.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Coherent Changes in Neural Motor Network Activity during Levodopa-Induced Dyskinesia in a Rat Model of Parkinson's Disease.
J Integr Neurosci
December 2024
Federal State Budgetary Educational Institution, Institute of Theoretical and Experimental Biophysics, 142290 Pushchino, Russia.
Background: Long-term use of levodopa, a metabolic precursor of dopamine (DA) for alleviation of motor symptoms in Parkinson's disease (PD), can cause a serious side effect known as levodopa-induced dyskinesia (LID). With the development of LID, high-frequency gamma oscillations (~100 Hz) are registered in the motor cortex (MCx) in patients with PD and rats with experimental PD. Studying alterations in the activity within major components of motor networks during transition from levodopa-off state to dyskinesia can provide useful information about their contribution to the development of abnormal gamma oscillations and LID.
View Article and Find Full Text PDFMultimodal Therapeutic Exercises and Their Role in Mitigating Chemotherapy-Induced Peripheral Neuropathy: A Longitudinal Study on Patient Outcomes.
Cureus
November 2024
Department of Oncology, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.
Introduction A common side effect post chemotherapy is chemotherapy-induced peripheral neuropathy (CIPN). The purpose of this study was to investigate the effect of a multimodal exercise program compared to standard physical therapy in treating CIPN symptoms and improving daily living skills. Aim The aim of this study was to evaluate the effect of multimodal therapeutic exercises and their role in mitigating CIPN symptoms on the neuropathy score and instrumental activities of daily living.
View Article and Find Full Text PDFEffects of intermittent hand-foot hypothermia therapy on chemotherapy-induced peripheral neurotoxicity.
Support Care Cancer
December 2024
Tangshan People's Hospital, Tangshan, 063000, China.
Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect in patients with breast cancer undergoing chemotherapy. This study aimed to assess the effects of three different intermittent hypothermia temperatures applied to the hands and feet on CIPN symptoms in patients with breast cancer undergoing chemotherapy.
Methods: In total, 108 patients were randomly divided into three experimental groups (n = 36).
Resolution of Anterior Uveal Infiltration of Acute Lymphoblastic Leukemia After Chimeric Antigen Receptor T-Cell Therapy.
J Vitreoretin Dis
August 2024
University Hospitals Eye Institute, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
To present a case of acute B-cell lymphoblastic leukemia (B-ALL) ocular relapse treated with chimeric antigen receptor T-cell (CAR T) therapy. A retrospective case review was evaluated. A 69-year-old woman with a history of BALL presented with bilateral hypopyons and 3+ anterior chamber cells that responded to topical prednisolone.
View Article and Find Full Text PDFValacyclovir Induced Neurotoxicity, with Therapeutic Drug Monitoring, in a Hospital-Based Setting in the Netherlands.
Eur J Case Rep Intern Med
October 2024
Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Groningen, The Netherlands.
Background: Valacyclovir-induced neurotoxicity is a rare side effect. The aim of this study was to perform a retrospective analysis of patients with valacyclovir-induced neurotoxicity and establish valacyclovir plasma concentrations in a tertiary hospital between January 2018 and November 2022.
Case Descriptions: In total 208 patients were identified with measured acyclovir concentrations, and the electronic health records of these patients were analysed.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!