Four types of neurons were distinguished in the septum of the guinea pig: 1. Piriform neurons (perikaryons 20-25 microns) with two thick dendritic trunks and an axon which emerges from the perikaryon on the opposite side to the dendritic trunks. These neurons are the main type of cells in the investigated nuclei; 2. Triangular neurons (24-32 microns) with three thick dendritic trunks arising conically from the perikaryons and a thin axon emerging directly from the soma; 3. Fusiform neurons (35-40 microns) which have two thick dendritic trunks on both poles of the cell body and a thin axon emerging from the soma; 4. Multipolar neurons (30-35 microns) with 4-5 thick dendritic trunks which emerge conically from the perikaryon. The axon arises near one of the dendritic trunks.
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Acta Dermatovenerol Croat
November 2024
Prof. Miloš Nikolić, MD, PhD, University of Belgrade, School of Medicine,, Belgrade, Serbia;
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a very rare and aggressive hematologic malignancy, arising from plasmacytoid dendritic cells (pDCs). BPDCN frequently has, at least initially, exclusively cutaneous presentation. We present a 45-year-old woman with a 3-month history of rapidly evolving violaceous patches, infiltrated plaques, and bruise-like tumefactions, disseminated on her face and upper trunk.
View Article and Find Full Text PDFbioRxiv
October 2024
Department of Neurobiology and Neuroscience Institute, The University of Chicago, Chicago, IL, USA.
Purkinje cell (PC) dendrites are optimized to integrate the vast cerebellar input array and drive the sole cortical output. PCs are classically seen as stereotypical computational units, yet mouse PCs are morphologically diverse and those with multi-branched structure can receive non-canonical climbing fiber (CF) multi-innervation that confers independent compartment-specific signaling. While otherwise uncharacterized, human PCs are universally multi-branched.
View Article and Find Full Text PDFSci Rep
October 2024
School of Medicine, Institute for Systems Genomics, UConn Health, University of Connecticut Health, 263 Farmington Avenue, Farmington, CT, 06030, USA.
In calcium imaging studies, Ca transients are commonly interpreted as neuronal action potentials (APs). However, our findings demonstrate that robust optical Ca transients primarily stem from complex "AP-Plateaus", while simple APs lacking underlying depolarization envelopes produce much weaker photonic signatures. Under challenging in vivo conditions, these "AP-Plateaus" are likely to surpass noise levels, thus dominating the Ca recordings.
View Article and Find Full Text PDFCancer Sci
December 2024
Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Front Immunol
July 2024
Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Introduction: The intestinal immune system plays a pivotal role in the induction of immune responses against food. In the case of T cell response, dendritic cells (DCs) are especially important. However, the regulation of immune responses to food by intestinal DCs has been poorly described.
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