AI Article Synopsis
- The nucleus tractus solitarii (nTS) acts as the main hub for processing signals from peripheral chemoreceptors that detect changes in oxygen levels.
- Recent research highlights the importance of the NMDA glutamate receptor in triggering the initial response to low oxygen (hypoxic ventilatory response or HVR).
- There's also evidence that activating the platelet-derived growth factor (PDGF) beta receptor affects the later stages of HVR, suggesting a complex interplay of signaling pathways in nTS neurons that influences both immediate breathing responses and longer-term adaptations.
Article Abstract
The nucleus tractus solitarii (nTS) provides the initial central synaptic relay to peripheral chemoreceptor afferent inputs elicited by changes in oxygen tension. Insofar, the overall cumulative evidence pointing towards the N-methyl-D-aspartate (NMDA) glutamate receptor as the critical receptor underlying the early component of the hypoxic ventilatory response (HVR) is reviewed in detail. In addition, we will present recent findings supporting a role for platelet-derived growth factor (PDGF) beta receptor activation in modulation of the late phase of HVR. This evidence underscores the proposal of a working model for intracellular signaling pathways, downstream to the NMDA glutamate and PDGF-beta receptors in nTS neurons, which may contribute to both the ventilatory characteristics of the acute hypoxic response and to subsequently occurring functional adaptations and synaptic plasticity phenomena.
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| http://dx.doi.org/10.1016/s0034-5687(00)00129-8 | DOI Listing |
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