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Perioperative methadone compared to placebo in elderly hip fracture patients: a study protocol for a randomized controlled trial (MetaHip trial).
Trials
December 2024
Department of Orthopedics, University Hospital of Southern Denmark, Kresten Philipsensvej 15, Aabenraa, 6200, Denmark.
Background: Hip fractures are a source of severe pain among the elderly population and pose challenges due to limited analgesic tolerance. Perioperative methadone has shown promise in our pilot study suggesting a safe dose of 0.10 mg/kg, prompting further investigation into its benefits for elderly hip fracture patients.
View Article and Find Full Text PDFImproving diagnostic of cervical dysplasia among postmenopausal women aged ≥50 years using local vaginal oestrogen treatment prior to colposcopy: study protocol for a multicentre randomised controlled trial (the IDEAL study).
BMJ Open
June 2024
Department of Gynecology and Obstetrics, Aarhus University, Aarhus, Denmark.
Article Synopsis
- Colposcopy is crucial for detecting cervical precancerous lesions, especially in postmenopausal women, but challenges arise due to age-related cervical changes that could lead to missed diagnoses.
- This study aims to determine if pre-treatment with vaginal estrogen improves colposcopy effectiveness by increasing the visibility of the transformation zone, involving 150 women over 50 with abnormal cervical screening results.
- The study is ethically approved and will compare outcomes like the visibility of the transformation zone, detection rates of cervical lesions, and the side effects of estrogen treatment versus a placebo.
Impact of Peptide Sequences on Their Structure and Function: Mimicking of Virus-Like Nanoparticles for Nucleic Acid Delivery.
Chembiochem
January 2023
Molecular Biology, University of Duisburg-Essen, 45117, Essen, Germany.
We rationally designed a series of amphiphilic hepta-peptides enriched with a chemically conjugated guanidiniocarbonylpyrrole (GCP) unit at the lysine side chain. All peptides are composed of polar (GCP) and non-polar (cyclohexyl alanine) residues but differ in their sequence periodicity, resulting in different secondary as well as supramolecular structures. CD spectra revealed the assembly of β-sheet-, α-helical and random structures for peptides 1, 2 and 3, respectively.
View Article and Find Full Text PDFAn Integrated Multidisciplinary Rehabilitation Program Experienced by Patients with Chronic Low Back Pain.
Clin Med Res
December 2021
Department of Public Health, Faculty of Health, Aarhus University, Aarhus C, Denmark.
To examine how an integrated, multidisciplinary rehabilitation program was experienced by patients with chronic low back pain and to gain insight into how these patients integrated knowledge, skills, and behaviors obtained by the program into their everyday lives. A phenomenological hermeneutic design using Ricoeur's interpretation theory was used in the analysis. Data were generated through nine semi-structured interviews in patients with chronic low back pain.
View Article and Find Full Text PDFLocating hyperfunctioning parathyroid glands using C-Choline PET/CT: an inter- and intra-observer variation study.
Eur J Hybrid Imaging
July 2021
Department of Nuclear Medicine, Herlev and Gentofte Hospital, 2730, Herlev, Denmark.
Background: Use of C-Choline PET/CT is gaining ground in detecting hyperfunctioning parathyroid glands in primary hyperparathyroidism. The purpose of this study was to evaluate the robustness of C-Choline PET/CT by assessing intra- and inter-observer agreement to determine whether the method was reader sensitive and therefore should only be performed at highly specialised sites with a high number of cases. PET/CT images of 40 patients diagnosed with primary hyperparathyroidism were anonymised and evaluated three times by three readers: an expert reader and two non-experts (non-experts were experienced in PET/CT imaging, but not in C-Choline PET/CT in the setting of primary hyperparathyroidism).
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