Treatment with ceftriaxone may be accompanied by precipitation of ceftriaxone calcium salts in the gallbladder, called pseudolithiasis. We present a case, in which a formerly healthy five year-old girl developed symptomatic pseudolithiasis during treatment with Rocephalin. The symptoms and pseudolithiasis disappeared after a few days with symptomatic treatment and change of antibiotics.
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Indian Pediatr
August 2021
Department of Radiodiagnosis, Netaji Subhash Chandra Bose Medical College, Jabalpur, Madhya Pradesh.
Objectives: We reviewed hospital records of pediatric cholelithiasis to develop an etiology-based decision-making protocol.
Methods: This retrospective study was conducted on consecutive pediatric cholelithiasis patients from July, 2014 to June, 2019 in a tertiary care center. Pediatric cholelithiasis was classified according to etiology, and the outcome of medical/surgical treatment was noted.
Pediatr Surg Int
March 2014
Department of Surgery, Center for Prospective Clinical Trials, Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO, 64108, USA.
Purpose: Ceftriaxone has been associated with development of pseudolithiasis. In our institution, it is used for treatment of perforated appendicitis in children. This study evaluated the occurrence of ceftriaxone-related pseudolithiasis in this population.
View Article and Find Full Text PDFJ Med Ultrason (2001)
September 2008
Department of Pediatric General and Urogenital Surgery, Juntendo University, School of Medicine, Tokyo, Japan.
A 5-year-old boy who had pneumonia was treated in a neighboring hospital. Ceftriaxone was administrated 2 g/day divided into two equal intravenous doses. After 1 week of ceftriaxone therapy, the patient developed abdominal pain.
View Article and Find Full Text PDFJ Clin Ultrasound
June 2006
Department of Pediatrics, Trakya University Faculty of Medicine, Cocuk Sağliği ve Hastaliklari AD 22030 Edirne, Turkey.
Purpose: Ceftriaxone is known to induce reversible precipitations, known as pseudolithiasis, in the gallbladder and urinary tract. The aim of this study was to investigate the incidence and predisposing factors that contribute to this side effect.
Methods: A prospective study was conducted in 156 children admitted for the treatment of various infections with different daily ceftriaxone doses (50 mg/kg, 75 mg/kg, and 100 mg/kg).
Pharmacotherapy
October 2005
College of Pharmacy, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
Ceftriaxone is a commonly used third-generation cephalosporin that has antimicrobial activity against many gram-positive and gram-negative organisms. Generally, ceftriaxone is a safe antibiotic; however, symptomatic biliary sludge has been reported in rare instances, most of which have involved children. It is uncommon for ceftriaxone to cause increases in laboratory indexes, such as bilirubin levels.
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