In a double-blind study on 36 volunteers the effects of 250 mug/kg (--)delta-9-trans-tetrahydrocannabinol p.o. on objective and performance tests measuring psychoticism according to Eysenck were assessed. The hypothesis was tested that subjects treated with delta-9-THC differ from those receiving placebo in the same way as endogenous psychotics differ from normals. Confirmation was obtained in only 5 out of 19 variables. Four of these 5 variables may be considered as tests of concentration.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF00421474 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Linking medicinal cannabis to autotaxin-lysophosphatidic acid signaling.
Life Sci Alliance
February 2023
European Molecular Biology Laboratory, Grenoble, Grenoble, France
Autotaxin is primarily known for the formation of lysophosphatidic acid (LPA) from lysophosphatidylcholine. LPA is an important signaling phospholipid that can bind to six G protein-coupled receptors (LPA). The ATX-LPA signaling axis is a critical component in many physiological and pathophysiological conditions.
View Article and Find Full Text PDFAnti-Cancer Activity of Phytocannabinoids: Molecular Mechanisms and Potential in the Fight against Ovarian Cancer and Stem Cells.
Cancers (Basel)
September 2022
Institute of Plant Science, Agriculture Research Organization, Volcani Institute, Rishon LeZion 7505101, Israel.
Ovarian cancer (OC) is the most lethal gynecological malignancy, with about 70% of cases diagnosed only at an advanced stage. , which produces more than 150 phytocannabinoids, is used worldwide to alleviate numerous symptoms associated with various medical conditions. Recently, studies across a range of cancer types have demonstrated that the phytocannabinoids Δ-trans-tetrahydrocannabinol (THC) and cannabidiol (CBD) have anti-cancer activity in vitro and in vivo, but also the potential to increase other drugs' adverse effects.
View Article and Find Full Text PDFLong-term effectiveness and safety of medical cannabis administered through the metered-dose Syqe Inhaler.
Pain Rep
May 2022
Institute of Pain Medicine, Rambam Health Care Campus, Haifa, Israel.
Introduction: Preliminary clinical studies on medical cannabis (MC) treatment using the Syqe Inhaler showed short-term effectiveness and safety at very low and precise doses of MC.
Objectives: Here, we retrospectively analyzed "real-life" long-term data collected in real time on the potential effectiveness and safety of MC administered with this device.
Methods: Patients were monitored by Syqe's patient support program.
Fertilization Following Pollination Predominantly Decreases Phytocannabinoids Accumulation and Alters the Accumulation of Terpenoids in Cannabis Inflorescences.
Front Plant Sci
November 2021
The Laboratory of Cancer Biology and Cannabinoid Research, Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel.
In the last decades, growing evidence showed the therapeutic capabilities of plants. These capabilities were attributed to the specialized secondary metabolites stored in the glandular trichomes of female inflorescences, mainly phytocannabinoids and terpenoids. The accumulation of the metabolites in the flower is versatile and influenced by a largely unknown regulation system, attributed to genetic, developmental and environmental factors.
View Article and Find Full Text PDFProlonged Medical Cannabis Treatment is Associated With Quality of Life Improvement and Reduction of Analgesic Medication Consumption in Chronic Pain Patients.
Front Pharmacol
May 2021
Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel.
Chronic non-cancer pain (CNCP) is one of the most prevalent indications for medical cannabis (MC) treatment globally. In this study, we investigated CNCP parameters in patients during prolonged MC treatment, and assessed the interrelation between CNCP parameters and the chemical composition of MC chemovar used. A cross-sectional questionnaire-based study was performed in one-month intervals for the duration of six months.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!