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Inhaled alpha-1 antitrypsin (AAT) restores lower respiratory tract protease-antiprotease homoeostasis and reduces inflammation in AAT-deficient individuals: a randomised phase 2 study.
ERJ Open Res
January 2025
Kamada Ltd., Rehovot, Israel.
Background: Alpha-1 antitrypsin (AAT)-deficient individuals have a greater risk for developing COPD than individuals with normal AAT levels.
Methods: This was a double-blind, randomised, parallel group, placebo-controlled trial to examine the safety and tolerability of "Kamada-AAT for Inhalation" (inhaled AAT) in subjects with AAT deficiency, and to explore its effect on AAT and biomarkers in the lung epithelial lining fluid (ELF). 36 patients with severe AAT deficiency were randomised 2:1 to receive 80 mg or 160 mg inhaled AAT or placebo once daily for 12 weeks.
Improving care experiences for premenstrual symptoms and disorders in the United Kingdom (UK): a mixed-methods approach.
BMC Health Serv Res
January 2025
Cambridge Centre for Neuropsychiatric Research, Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.
Background: Poor care experiences are reported for premenstrual disorders, which may result in negative outcomes such as distress, reduced healthcare engagement, and delays to diagnosis. This research aimed to explore healthcare experiences for premenstrual symptoms in the United Kingdom and identify areas for potential improvements based on participant responses.
Method: An online survey was delivered, with participants recruited via social media.
Bacteraemia after transcatheter aortic valve implantation: a nationwide cohort study.
Heart
December 2024
Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Background: Bacteraemia and infective endocarditis (IE) are rare but severe complications of transcatheter aortic valve implantation (TAVI). Limited data exist on the incidence and microbiological profile of early bacteraemia in this population. This study aimed to evaluate the 6-month incidence of bacteraemia, IE and associated mortality following TAVI.
View Article and Find Full Text PDFEffects of Extremely Low-Frequency Electromagnetic Field Treatment on ASD Symptoms in Children: A Pilot Study.
Brain Sci
December 2024
Leaps and Bounds Exceptional Services ABA (Applied Behaviour Analysis) Program, Leaps and Bounds Clinic, 13045 Jane Street, King City, ON L7B 1A3, Canada.
Background/objectives: Autism Spectrum Disorder (ASD) are neurodevelopmental disorders marked by challenges in social interaction, communication, and repetitive behaviors. People with ASD may exhibit repetitive behaviors, unique ways of learning, and different ways of interacting with the world. The term "spectrum" reflects the wide variability in how ASD manifests in individuals, including differences in abilities, symptoms, and support needs, and conditions characterized by difficulties in social interactions, communication, restricted interests, and repetitive behaviors.
View Article and Find Full Text PDFPentafluoroorthotellurate Uncovered: Theoretical Perspectives on an Extremely Electronegative Group.
Inorg Chem
January 2025
Departamento de Química Física and Instituto de Biocomputación y Física de Sistemas Complejos (BIFI), Universidad de Zaragoza, Zaragoza 50009, Spain.
Article Synopsis
- The pentafluoroorthotellurate group (-OTeF, teflate) is a potent electron-withdrawing substitute for fluoride, known for its stability and size, which helps avoid bridging ligand behavior.
- This study employs advanced Quantum Chemical Topology methods to analyze the electronic structure and bonding of the teflate group, comparing its electronegativity with halogens and investigating the interactions in various XOTeF systems.
- Findings reveal that while teflate exhibits strong electron-withdrawing abilities akin to fluorine, its bonding is predominantly ionic and shares similar electronegativity traits with other O-donor groups.
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