AI Article Synopsis
- HTLV-I infection was originally linked to T cell leukemia and neurologic diseases, but is now also associated with various autoimmune disorders like Sjogren's syndrome and uveitis.
- A study on infected rabbits showed that all had antibodies against keratin and thyroglobulin, with some reacting to collagen, while other autoantibodies were rare.
- The autoimmune responses were confirmed as being related to HTLV-I infection because uninfected controls did not show similar autoantibodies, and evidence suggested that the infection itself triggered these reactions.
Article Abstract
Human T cell leukemia virus type I (HTLV-I) infection was initially associated with T cell leukemia and a progressive neurologic disease but has since been linked to an increasing number of autoimmune disorders, including Sjogren's syndrome, uveitis, and polyarthritis. A survey of serum samples from a rabbit model of HTLV-I infection revealed that all had antibodies against keratin and thyroglobulin. Sera from several infected rabbits also reacted with collagen, while antibody reactions with other autoantigens tested, including DNA, were rare and sporadic. In addition to antibodies, cellular reactivity to keratin, but not thyroglobulin, was demonstrated by cellular proliferation in presence of IL-2 and keratin. Expanded cell cultures were positive for T cell activation markers and CD8. Association of the auto-reactivity with HTLV-I infection rather than random anti-cellular responses was supported by the fact that no antikeratin or antithyroglobulin was seen in uninfected controls, including that inoculated with uninfected lymphocytes. Finding autoantibodies in rabbits infected using naked HTLV-I DNA clones provided further assurance that infection induced the autoimmune reactions detected.
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| http://dx.doi.org/10.3109/08916930008995988 | DOI Listing |
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