Human herpesvirus 6 (HHV-6) has been proposed as a potential cofactor in the progression of human immunodeficiency virus type 1 (HIV-1) disease. We used the SCID-hu Thy/Liv mouse model to evaluate the in vivo interactions between HHV-6 and HIV-1. Our results demonstrate that HHV-6 and HIV-1 can simultaneously replicate in the human thymus in vivo. In this model, however, the presence of one virus appears not to modify the replication or cytopathicity of the other.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC116384 | PMC |
| http://dx.doi.org/10.1128/jvi.74.18.8726-8731.2000 | DOI Listing |
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