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Upregulated let-7 expression in the follicular fluid of patients with endometriomas leads to dysfunction of granulosa cells through targeting of IGF1R.
Hum Reprod
January 2025
Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China.
Study Question: What molecular mechanisms underlie the decline in ovarian reserve as the number and quality of oocytes decrease in patients with ovarian endometriomas (OEM)?
Summary Answer: Elevated expression of the let-7 micro(mi)RNAs in the follicular microenvironment of OEM-affected ovaries targets the expression of type 1 insulin-like growth factor receptor (IGF1R) in granulosa cell (GC) and disrupts their proliferation, steroid hormone secretion levels, adenosine triphosphate (ATP) energy metabolism, and reactive oxygen species (ROS) oxidative stress levels.
What Is Known Already: Patients with OEM exhibit diminished ovarian reserve, characterized by reduced oocyte quantity and quality. Fibrotic changes in the ovarian tissue surrounding the OEM create a disruptive microenvironment for follicular growth and development.
Cost-effectiveness of hysterectomy, first- and second-generation endometrial ablation, and levonorgestrel-releasing device for treatment of heavy menstrual bleeding: a systematic review.
Expert Rev Pharmacoecon Outcomes Res
October 2024
Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran.
Objectives: This study aims to provide a clear understanding of the relative economic evaluation of hysterectomy, first- and second-generation endometrial ablation, and levonorgestrel-releasing intrauterine device for treatment of heavy menstrual bleeding.
Methods: A comprehensive search was conducted without restrictions until October 5, 2023, across databases including PubMed, EMBASE, Scopus, Cochrane, and others. The review included studies using full economic evaluation methods to compare treatments, excluding review articles, editorials, abstracts, and non-English articles.
Article Synopsis
- The study aims to compare the effectiveness of first and second-generation endometrial ablation (EA) techniques, medical treatments, and invasive surgeries for managing abnormal uterine bleeding (AUB).
- It is a systematic review and network meta-analysis that includes data from 49 high-quality randomized controlled trials involving over 8,000 women.
- The results indicate that uterine balloon ablation shows significantly higher rates of amenorrhea compared to other techniques, both in the short term and long-term follow-up.
Ultrasound Appearance of the Endometrium Post-Radiofrequency Ablation.
J Ultrasound Med
June 2024
Department of Obstetrics & Gynecology, TriHealth Hospital System, Cincinnati, Ohio, USA.
Objective: To describe the ultrasonographic appearance of the post-ablative endometrium to improve knowledge of its sonographic findings.
Methods: This was an Institutional Review Board approved prospective study of patients who underwent second-generation endometrial ablation from 2016 to 2019 at a single health system. Patients had postoperative transvaginal ultrasounds at 2, 6, and 12 months.
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