A multi-centre double-blind crossover study was carried out in 70 hospitalised patients with rheumatoid arthritis to compare the activity of diftalone, a new anti-inflammatory agen, with that of indomethacin. Patients received either 750 mg. diftalone or 100 mg. indomethacin daily for 2 weeks and were then crossed over to the alternative treatment for a further 2 weeks. Routine clinical and laboratory assessments of disease activity were carried out before the start of the trial and after each treatment period. The results indicate that both drugs produced a favourable response and that there was no statistically significant difference between them in the parameters measure, except for the erythrocyte sedimentation rate which fell only after the administration of diftalone. Patient and physician assessments on the course of the disease were in general agreement and were favourable to the same extent for both treatments. Both products were well tolerated and there were few reports of side-effects.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1185/03007997509113657 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Carcinogenic activity in mice of diftalone, an anti-inflammatory agent.
J Cancer Res Clin Oncol
February 1985
The anti-inflammatory agent diftalone was administered in the diet to male and female BALB/c mice at 300-, 600-, and 1200-ppm dose levels for 80 weeks, starting at 8 weeks of age. The animals were kept under observation until 126-128 weeks of age, when the experiment was terminated. Diftalone treatment at the highest dose was hepatotoxic and induced hepatocellular tumors in females, angiomas of the liver in males, and angiosarcomas of the liver in male and female mice.
View Article and Find Full Text PDFNonsteroid anti-inflammatory agents: regulators of the phagocytic secretion of lysosomal enzymes from guinea-pig neutrophils.
J Pharmacol Exp Ther
November 1978
Several nonsteroid anti-inflammatory agents were evaluated for their capacity to modulate phagocytosis by and lysosomal enzyme secretion from polymorphonuclear neutrophils. During cell contact with and phagocytosis of serum-treated zymosan particles, guinea-pig neutrophils demonstrated a selective extracellular release of lysosome granule-associated beta-glucuronidase and acid protease but not cytoplasmic lactate dehydrogenase. Ketoprofen, suprofen, diftalone, benoxaprofen and Abbott 29590 inhibited particle uptake by and lysosomal enzyme release from neutrophils incubated with zymosan in Krebs-Ringer phosphate medium containing 7.
View Article and Find Full Text PDFThe behaviour of bronchial reactivity to PGF2alpha was studied in asthmatic patients under various experimental conditions. Premedication with aminophylline, i.v.
View Article and Find Full Text PDFThe therapeutic effectiveness and tolerability of diphthalone and indomethacine administered for long periods were compared in 10 patients suffering from rheumatoid arthritis in the active phase. Each patient was treated with one of the two drugs on a double blind basis. Diphthalone proved to be more active than indomethacine on morning stiffness and on hand grip strength.
View Article and Find Full Text PDFA long-term (two years) double-blind, comparative trial of diftalone (Aladione) 500 mg versus indomethacin 75 mg per day, in rheumatoid arthritis (thirty-two patients), has shown a similar effectiveness for both anti-inflammatory agents on various clinical parameters of disease activity, some better results being obtained for diftalone as regards the capacity of reducing erythrocyte sedimentation rate. The tolerability of diftalone proved to be somewhat superior, as is shown by the lower number of patients complaining of side-effects or being dropped out for intolerance, and by the lower frequency of central nervous system disturbances.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!