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Prognostic Value of Retinoblastoma in Small Intestinal Adenocarcinoma: A Multicenter Retrospective Study.
J Korean Med Sci
December 2024
Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Background: The retinoblastoma (RB) protein which is encoded by gene selectively provides a cell type-specific function in malignancies. In colorectal carcinoma, RB has been highly expressed and related cyclin/cyclin-dependent kinase 4/6 inhibitors have shown improved therapeutic effects in some patients. However, little is known about RB in small intestinal adenocarcinoma (SIAC).
View Article and Find Full Text PDFEndoscopic Monitoring of Treatment of Indeterminate Intestinal Lesions in a Prospective "Real-Life" Cohort in Eastern India Where Tuberculosis Remains Endemic: Distinguishing Intestinal Tuberculosis From Crohn's Disease.
Cureus
December 2024
Gastroenterology, Institute of Post Graduate Medical Education and Research, Kolkata, IND.
Introduction It is sometimes difficult to differentiate between intestinal tuberculosis (ITB) and Crohn's disease (CD) in India, as both conditions may mimic each other. The aim was to differentiate ITB from CD in indeterminate intestinal lesions with a therapeutic trial of anti-tubercular therapy (ATT) and follow-up to find out the clinical, endoscopic, radiological, and histological predictors for differentiation between ITB and CD. Methods A prospective observational cohort study of patients diagnosed with ITB and CD according to the Asia-Pacific Guidelines in a "real-life" clinical setting was conducted.
View Article and Find Full Text PDFClinicopathologic findings in a cohort of metastases to the stomach.
Hum Pathol
November 2024
Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address:
Aims: Metastatic tumors to the stomach can mimic primary gastric adenocarcinoma or be subtle and difficult to identify. The current study aimed to characterize the clinicopathology of metastases to the stomach to aid in diagnosis.
Methods And Results: Forty-three metastatic tumors and 30 primary gastric adenocarcinoma cases were reviewed.
Burkitt's lymphoma with multi-organ involvement.
Int J Surg Case Rep
December 2024
Department of Pathology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Article Synopsis
- Burkitt's lymphoma (BL) is a fast-growing B-cell non-Hodgkin lymphoma that often affects multiple organs, including rare cases in the gastrointestinal tract, which makes up less than 2% of small intestinal cancers.!* -
- A 34-year-old man with sickle cell trait showed symptoms like abdominal pain and weight loss, and after imaging and surgery, he was diagnosed with Burkitt's lymphoma that affected his cecum, appendix, peritoneum, and bone marrow.!* -
- The case emphasizes the significance of recognizing the fast progression of BL and the "starry sky" pattern in histopathology for accurate diagnosis and correlation in clinical settings.!*
Coexistence of Intestinal Spirochetosis and Colorectal Cancer: Could the Coil be Carcinogenic?
ACG Case Rep J
November 2024
Division of Gastroenterology, Hepatology, and Nutrition, University of Florida College of Medicine, North Florida/South Georgia Veterans Health System, Gainesville, FL.
Intestinal spirochetosis (IS) is an infectious gastrointestinal disease caused by bacteria. We detail an exceedingly rare case of IS with concomitant invasive colorectal adenocarcinoma (CRC) in a 58-year-old man presenting with abdominal discomfort and fever. Colonoscopic evaluation revealed abnormal-appearing, nodular cecal mucosa and a 35 mm rectosigmoid mass.
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