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A predictive model based on the gut microbiota improves the diagnostic effect in patients with rheumatoid arthritis.
Rheumatology (Oxford)
January 2025
School of Management, Shanxi Medical University, Taiyuan, China.
Objectives: Rheumatoid arthritis (RA) is a chronic, destructive autoimmune disorder predominantly targeting the joints, with gut microbiota dysbiosis being intricately associated with its progression. The aim of the present study was to develop of effective early diagnostic methods for early RA based on gut microbiota.
Methods: A cohort comprising 262 RA patients and 475 healthy controls (HCs) was recruited.
Progesterone induces meiosis through two obligate co-receptors with PLA2 activity.
Elife
January 2025
Calcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar.
The steroid hormone progesterone (P4) regulates multiple aspects of reproductive and metabolic physiology. Classical P4 signaling operates through nuclear receptors that regulate transcription. In addition, P4 signals through membrane P4 receptors (mPRs) in a rapid nongenomic modality.
View Article and Find Full Text PDFSystematic analyses uncover robust salivary microbial signatures and host-microbiome perturbations in oral squamous cell carcinoma.
mSystems
January 2025
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, China.
Unlabelled: Oral squamous cell carcinoma (OSCC) is a prevalent malignancy in the oral-maxillofacial region with a poor prognosis. Oral microbiomes play a potential role in the pathogenesis of this disease. However, findings from individual studies have been inconsistent, and a comprehensive understanding of OSCC-associated microbiome dysbiosis remains elusive.
View Article and Find Full Text PDFCardiac dilation, energy stress and ventricular remodeling: insights from prolonged voluntary exercise in male mice with TAC-induced HFpEF.
J Appl Physiol (1985)
January 2025
Department of Anatomy, Dalian Medical University, Dalian, Liaoning, China.
Exercise in heart failure with preserved ejection fraction (HFpEF) remains a hot topic, although current treatment strategies have not been shown to improve the long-term prognosis of HFpEF. Previous studies have mostly focused on the roles of endurance training, the mechanisms underlying long-term voluntary exercise have not been elucidated. The purpose of the present analysis was to evaluate alterations in cardiac function in HFpEF mice (HFpEF-Sed) after 6 weeks of voluntary running (HFpEF-Ex), investigate mechanisms, and compare the effects with fluoxetine (HFpEF-FLX).
View Article and Find Full Text PDFInvestigating the influence of blood meal sources on the composition of culturable haemolytic gut bacteria of a wild-caught BTV vector Culicoides oxystoma Kieffer (Diptera: Ceratopogonidae).
Med Vet Entomol
January 2025
Entomology Research Unit, Department of Zoology, The University of Burdwan, Burdwan, India.
Culicoides oxystoma Kieffer (Diptera: Ceratopogonidae) transmits many pathogens, including seven viruses, four protozoa and one nematode. This species has a wide distribution range across northern Afro-tropical, Palearctic, Australian, Indo-Malayan realms with a broad host spectrum, including cattle, buffaloes, sheep, pigs, dogs, horses and even humans. The heterogeneous nature of Culicoides' blood-feeding patterns is well documented, but the influence of various host blood meal sources on gut bacterial composition remains scant.
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