Breathlessness is the most common symptom that limits exercise in patients with chronic obstructive pulmonary disease and who may receive benefit from exercise training programmes. Exercise intensity may influence the physiological benefits of the programme. Although the exact underlying physiopathological mechanism is still unclear, there is laboratory evidence that continuous positive airway pressure and other modalities of mechanical ventilation (delivered either by mouthpiece or facial or nasal masks) may reduce breathlessness and increase exercise tolerance in these patients, in order to allow them to reach a higher exercise intensity. Respiratory muscle unloading and a reduction in intrinsic positive end-expiratory pressure have been considered among the potential mechanisms underlying these effects. The role of mechanical ventilation in pulmonary rehabilitation programmes, if any, is still to be defined.
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Nutr Metab Cardiovasc Dis
February 2025
Division of Sports Medicine and Science, Graduate School of Physical Education, Kyung Hee University, Yongin, 17104, Republic of Korea; Obesity and Physical Activity Research Laboratory, Kyung Hee University, Yongin, 17104, Republic of Korea. Electronic address:
Background And Aim: We investigated the effects of brief, intense stair climbing on cardiorespiratory fitness (CRF) and cardiometabolic risk factors in young Korean men with obesity.
Methods And Results: Twenty-four healthy men (age: 25.8 ± 2.
J Neuroimmunol
March 2025
Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Geriatric Medical Research Center, Beijing, China; Beijing Institute of Major Brain Diseases, Beijing, China. Electronic address:
Vascular cognitive impairment (VCI) is a syndrome characterized by cognitive decline resulting from insufficient perfusion to the entire brain or specific brain regions. The lack of a clear understanding of the mechanisms linking cerebrovascular disease to cognitive impairment has impeded the development of targeted treatments for VCI. Increasing evidence indicates that exercise may offer significant benefits for patients with VCI.
View Article and Find Full Text PDFMed Sci Sports Exerc
March 2025
Radboud university medical center, Department of Medical Biosciences, Nijmegen, THE NETHERLANDS.
Purpose: The cardiometabolic benefits of replacing sedentary time with light-intensity physical activity (LIPA) are unclear. We studied the associations of hypothetically reallocating sedentary time towards LIPA with changes in cardiometabolic risk factors using thigh-worn accelerometery. We also explored whether reallocation effects differed across subgroups with low, moderate, and high sedentary time and compared proportionally similar reallocations to either LIPA or moderate-to-vigorous physical activity (MVPA).
View Article and Find Full Text PDFMed Sci Sports Exerc
March 2025
Nazarbayev University School of Medicine, Astana, KAZAKHSTAN.
Purpose: We sought to evaluate the effect of intensive physical training on left ventricular (LV) hemodynamic forces (HDF) in athletes.
Methods: Forty professional endurance athletes were evaluated at the beginning of their training cycle (off-season) and after a period of aerobic isotonic dynamic exercise (peak training period) using cardiac magnetic resonance (CMR). Images were analyzed off-line using dedicated software.
Am J Hosp Palliat Care
March 2025
Palliative and End of Life Care, Specialty Programs, Alberta Health Services, Edmonton, AB, Canada.
BackgroundDyspnea is a prevalent and distressing symptom in interstitial lung diseases with significant effects on patients' quality of life and associated with poorer prognosis. Guidelines recommend a multidimensional dyspnea assessment tool. We developed a validated 9-item scale, the Edmonton Dyspnea Inventory (EDI), in which dyspnea severity is rated across different settings including at rest, during activities of daily living, and self-reported exercise and crises.
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