Background: Endogenous hyaluronan has been found in different tissues in the normal and traumatized eye. However, the main source, the biological aspects and the full potential role of hyloronan are still unclear.
Methods: Hyaluronan production was studied both in organ culture and in vivo, using a double-label protocol with [35S]sulfate and [3H]glucosamine.
Results: [3H]glucosamine and [35S]sulfate were incorporated into hyaluronan and sulfated glycosaminoglycans in normal and in traumatized iris tissue in organ culture and in vivo. There was low relative hyaluronan synthesis in vivo, only 2% of total incorporated [3H]glucosamine in normal irides. Increased relative incorporation of [3H]glucosamine into hyaluronan was seen after operative trauma to iris tissue both in vivo and in vitro.
Conclusion: Our findings demonstrate synthesis of hyaluronan by normal and traumatized iris. The iris seems to be the most important source of aqueous hyaluronan.
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