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Circulating chemokine levels and receptor polymorphisms have potential as biomarkers for fibrosis stages in patients with chronic hepatitis C infection.
Mol Biol Rep
January 2025
Faculty of Medicine, Department of Gastroenterology, Mersin University, Mersin, Turkey.
Background: Chemokines and their receptors, which regulate lymphoid organ development and immune cell trafficking, are integral to the mechanisms underlying viral control, hepatic inflammation, and liver damage in chronic hepatitis C (CHC) infection. This study explores the potential relationship between serum chemokine levels/polymorphisms and hepatitis C infection in affected individuals, with a particular focus on their utility as biomarkers across different stages of fibrosis.
Methods And Results: Serum levels of the chemokines CXCL11, CXCL12, and CXCL16 were measured in patients with mild/moderate and advanced fibrosis due to CHC, as well as in healthy controls, using the ELISA method.
Cardiovascular effects of lactate in healthy adults.
Crit Care
January 2025
Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark.
Background: Low-volume hypertonic solutions, such as half-molar lactate (LAC), may be a potential treatment used for fluid resuscitation. This study aimed to evaluate the underlying cardiovascular effects and mechanisms of LAC infusion compared to sodium-matched hypertonic sodium chloride (SAL).
Methods: Eight healthy male participants were randomized in a controlled, single-blinded, crossover study.
Benthic macroinvertebrate diversity and function in an agricultural constructed wetland affected by agrochemical pressure (Seine-et-Marne, France).
Environ Sci Pollut Res Int
January 2025
University Paris-Saclay, INRAE, HYCAR, 1 Rue Pierre-Gilles de Gennes, 10030, 92761, Antony Cedex, CS, France.
Constructed wetlands (CWs), originally designed to mitigate chemical water pollution, often host noticeable aquatic fauna. However, little is known about the impact of the contaminants circulating within CWs on this local fauna, questioning the role of CWs as ecological refuges or traps. We aimed to assess the potential of an agricultural CWs in northern France to act as an ecological trap for aquatic fauna and the potential consequences on wetland functioning.
View Article and Find Full Text PDFClinical feasibility of deep learning-driven magnetic resonance angiography collateral map in acute anterior circulation ischemic stroke.
Sci Rep
January 2025
DeepClue Inc., Deajeon, Republic of Korea.
To validate the clinical feasibility of deep learning-driven magnetic resonance angiography (DL-driven MRA) collateral map in acute ischemic stroke. We employed a 3D multitask regression and ordinal regression deep neural network, called as 3D-MROD-Net, to generate DL-driven MRA collateral maps. Two raters graded the collateral perfusion scores of both conventional and DL-driven MRA collateral maps and measured the grading time.
View Article and Find Full Text PDFAssociation of thrombus enhancement with mortality following endovascular therapy in patients with acute anterior circulation stroke.
J Neurointerv Surg
January 2025
Department of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, Fujian, China
Background: Thrombus enhancement sign (TES) has emerged as a potential imaging biomarker in patients with acute ischemic stroke (AIS) undergoing endovascular thrombectomy (EVT).
Objective: To evaluate the prognostic value of TES on 90-day mortality and functional outcomes.
Methods: We conducted a prospective, two-center study involving 323 patients with AIS treated with EVT.
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