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[Evaluation of allogenic complement-regulating proteins in the peripheral blood cells of chimeric rat models harboring human cord blood stem cells].
Nan Fang Yi Ke Da Xue Xue Bao
August 2008
Department of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Objective: To analyze the mechanisms of surrogate tolerogenesis induced by chimeric donors.
Methods: Hematopoietic stem cells (HSCs) from human cord blood were transplanted into fetal rats via intrauterine injection and infused into the liver of the neonatal rats to establish chimeric rat models with human HSCs. Four weeks after birth, flow cytometry was performed to analyze the percentages of human CD45 (hCD45), CD55 (hCD55) and CD59 (hCD59)-positive cells in the peripheral blood cells of the chimeric rats.
Chimeric pig hearts resist hyperacute rejection in ex vivo perfusion model.
J Extra Corpor Technol
September 2001
Department of Surgery, University of Nebraska Medical Center, Omaha 68198-7690, USA.
With surrogate tolerogenesis. the recipient immune system is engrafted within the donor pig before organ transplant. Chimeric pig hearts may resist hyperacute rejection by inducing accommodation.
View Article and Find Full Text PDFSurrogate tolerogenesis: possible pretransplant induction of accommodation of pig xenografts.
Transplant Proc
August 2000
Ximerex, Inc, Omaha, Nebraska 68116-2461, USA.
Effect of surrogate tolerogenesis on the vascular rejection of pig heart xenografts.
Transplantation
January 2000
Department of Surgery, University of Nebraska Medical Center, Omaha 68198, USA.
Background: Organ xenografts are fulminantly rejected by antibody-mediated vascular rejection. Surrogate tolerogenesis (ST), the induction of tolerance within the donor, is effective with aorta xenografts. This preliminary study assesses the effect of ST on preformed antibodies and rejection of porcine heart xenografts.
View Article and Find Full Text PDFEvidence for engraftment of human bone marrow cells in non-lethally irradiated baboons.
Transplantation
December 1997
Thomas E. Starzl Transplantation Institute and the Department of Surgery, University of Pittsburgh Medical Center, Pennsylvania 15261, USA.
Background: Prior to organ harvesting, an attempt was made to modulate the donor's immune responses against prospective xenogeneic recipients by infusion of "recipient-type" bone marrow.
Methods: For this purpose, baboons conditioned with total lymphoid irradiation were given 6 x 10(8) unmodified human bone marrow cells/kg body weight with no subsequent treatment.
Results: Animals survived until they were euthanized at 18 months.
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