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Aflatoxin B can aggravate BALB/c mice allergy to ovalbumin through changing their Th2 cells immune responses.
Toxicon
June 2023
College of Food Science & Technology, Nanchang University, Nanchang, 330031, PR China. Electronic address:
Foods contaminated by Aflatoxin B (AFB) frequently happen in the world and can cause a lot healthy damages to human beings, meanwhile, some of these foods are easily irritate food allergy. To investigate the effect of AFB exposure on food allergy, three doses of AFB were set, including 0.3 μg/kg · bw (LDAF), 7.
View Article and Find Full Text PDFMetabolic reprogramming of stromal fibroblasts by melanoma exosome microRNA favours a pre-metastatic microenvironment.
Sci Rep
August 2018
Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Local acidification of stroma is proposed to favour pre-metastatic niche formation but the mechanism of initiation is unclear. We investigated whether Human Melanoma-derived exosomes (HMEX) could reprogram human adult dermal fibroblasts (HADF) and cause extracellular acidification. HMEX were isolated from supernatants of six melanoma cell lines (3 BRAF V600E mutant cell lines and 3 BRAF wild-type cell lines) using ultracentrifugation or Size Exclusion Chromatography (SEC).
View Article and Find Full Text PDFEffects of carbon monoxide on early dysfunction and microangiopathy following GalT-KO porcine pulmonary xenotransplantation in cynomolgus monkeys.
Xenotransplantation
January 2018
Division of Organ Replacement and Xenotransplantation Surgery, Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan.
Background: Despite progress in the current genetic manipulation of donor pigs, most non-human primates were lost within a day of receiving porcine lung transplants. We previously reported that carbon monoxide (CO) treatment improved pulmonary function in an allogeneic lung transplant (LTx) model using miniature swine. In this study, we evaluated whether the perioperative treatment with low-dose inhalation of CO has beneficial effects on porcine lung xenografts in cynomolgus monkeys (cynos).
View Article and Find Full Text PDFDAF-shielded baculovirus-vectored vaccine enhances protection against malaria sporozoite challenge in mice.
Malar J
September 2017
Laboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, First Natural Science Building 1A219, Kakuma-machi, Kanazawa, 920-1192, Japan.
Background: Previous studies have shown that the baculovirus-vectored vaccine based on the "baculovirus dual expression system (BDES)" is an effective vaccine delivery platform for malaria. However, a point of weakness remaining for use of this vaccine platform in vivo concerns viral inactivation by serum complement. In an effort to achieve complement resistance, the gene encoding the human decay-accelerating factor (hDAF) was incorporated into the BDES malaria vaccine expressing the Plasmodium falciparum circumsporozoite protein (PfCSP).
View Article and Find Full Text PDFProduction of α1,3-galactosyltransferase targeted pigs using transcription activator-like effector nuclease-mediated genome editing technology.
J Vet Sci
March 2016
MGENPLUS Biotechnology Research Institute, Seoul 08511, Korea.; Department of Animal Science & Technology, Sunchon National University, Suncheon 57922, Korea.
Recent developments in genome editing technology using meganucleases demonstrate an efficient method of producing gene edited pigs. In this study, we examined the effectiveness of the transcription activator-like effector nuclease (TALEN) system in generating specific mutations on the pig genome. Specific TALEN was designed to induce a double-strand break on exon 9 of the porcine α1,3-galactosyltransferase (GGTA1) gene as it is the main cause of hyperacute rejection after xenotransplantation.
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