Objective: To report our experience with the use of Levovist in echocardiographic studies.
Method: We studied consecutively patients with suboptimal echocardiographic studies. A bolus of 4 gr @ 400 mg/ml was administered via antecubital vein and a second echocardiogram was performed during the ensuing minutes.
Results: Between June and July 1998 we studied 16 patients with suboptimal echocardiograms, seven males and nine females, ages 29-77. There were six patients with coronary artery disease (CAD), three with mitral regurgitation (MR), one with dynamic subaortic stenosis, five with right chambers dilatation and one with a left atrial tumor. No patient referred discomfort or had any complication-with Levovist. The mean time of the contrast effect was nine minutes. A better delineation of endocardial borders was observed this allowed better evaluation of wall motion and left ventricular function in patients with CAD. There was Doppler enhancement in patients with MR and subaortic stenosis facilitating its evaluation. We documented atrial septal defect non visualized previously in two of five patients with right chambers dilatation. There was a better delineation of the left atrial tumor.
Conclusions: Levovist showed enhancement of all Doppler modalities and facilitated de evaluation of MR, left ventricular function, subaortic stenosis and a cardiac tumor. It was safe and well tolerated.
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Child Care Health Dev
January 2025
Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Background: Since 2001, the American Academy of Pediatrics has released and twice revised guidelines tasking paediatricians with screening children for developmental disorders, but diagnoses are often delayed. Paediatricians in the United States are also responsible for referring patients with identified concerns for services and for managing their long-term care.
Objectives: This review aims to chronologically synthesize available literature about paediatricians' perspectives surrounding their roles in identifying and managing early childhood disorders and to identify how future interventions can best address these perspectives.
Eur Respir Rev
January 2025
Dept of Public Health and Primary Care, Academic Centre for Nursing and Midwifery, KU Leuven - University of Leuven, Leuven, Belgium
Introduction: People with idiopathic pulmonary fibrosis (IPF) and other forms of progressive pulmonary fibrosis (PPF) have a high symptom burden and a poor health-related quality of life (HRQoL). Despite efforts to offer specialised treatment, clinical care for these patients remains suboptimal and several nonmedical needs remain unaddressed. Developing a core outcome set (COS) can help to identify a minimum set of agreed-upon outcomes that should be measured and acted-upon in clinical care.
View Article and Find Full Text PDFObjective: To assess the Knowledge, Attitudes and Practices (KAP) among healthcare professionals in managing patients with coexisting hypertension and bronchial asthma.
Design: A cross-sectional survey. The reporting of this study followed the Strengthening the Reporting of Observational Studies in Epidemiology checklist.
RMD Open
January 2025
First Department of Internal Medicine, University of Occupational and Environmental Health Japan, Kitakyushu, Japan
Objectives: This study aimed to identify characteristics of patients with rheumatoid arthritis (RA) with an inadequate response to Janus kinase inhibitors (JAKi-IR) and evaluate the efficacy and safety of subsequent treatments.
Methods: This study included 434 patients with RA who started JAKi treatment. JAKi-IR patients were those who switched to another drug due to inadequate response or did not reach low disease activity within 26 weeks of beginning JAKi.
Cancer Nurs
January 2025
Author Affiliations: The Nethersole School of Nursing, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong (Ms Chen and Drs Ng, Zhang, and Chan); and Nursing Department, People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, China (Ms Chen).
Background: Patients with gastrointestinal tract cancer reported suboptimal adherence to oral anticancer agents (OAAs), reducing their therapeutic benefit and increasing mortality risk. A scoping review can comprehensively map available evidence on adherence to OAAs and inform appropriate support to improve treatment outcomes.
Objective: The aim of this study was to comprehensively map studies on adherence to OAAs among adults with gastrointestinal tract cancer, including the adherence rate, nonadherence reasons, influential factors, management strategies, and theories that guide these studies.
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