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Analysis of Measles and Rubella Immunoglobulin G Titers in COVID-19 Patients.
Risk Manag Healthc Policy
November 2024
Department of Family Medicine, Samsun University Faculty of Medicine, Samsun, Turkey.
Background: The objective of this study is to compare the measles immunoglobulin G (IgG) and rubella IgG levels in patient groups with mild and severe COVID-19 disease and reveal the possible relationship.
Methods: This study was conducted among COVID-19-confirmed patients over 18, under 65 years of age. This study involved 75 participants- divided into two groups.
Evaluation of the focus reduction neutralization and ELISA tests compared to the plaque reduction neutralization test for the detection of antibodies against measles virus.
Biologicals
November 2024
Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:
Article Synopsis
- Measles, caused by the measles virus, remains a global health challenge despite the availability of an effective vaccine, with a need for better methods to assess community immunity.* -
- The enzyme-linked immunosorbent assay (ELISA) is the standard immunity test but often fails to detect low antibody levels, while the more accurate plaque reduction neutralization test (PRNT) is impractical for regular use.* -
- This study validated the focus reduction neutralization test (FRNT) as a reliable alternative to PRNT, demonstrating that FRNT provides similar sensitivity and perfect correlation in identifying protective antibodies compared to PRNT.*
A Cross-Sectional Study of Measles-Specific Antibody Levels in Australian Blood Donors-Implications for Measles Post-Elimination Countries.
Vaccines (Basel)
July 2024
Hunter New England Population Health, Hunter New England Local Health District, Locked Bag 10, Wallsend, NSW 2287, Australia.
Passive immunisation with normal human immunoglobulin (NHIG) is recommended as post-exposure prophylaxis (PEP) for higher-risk measles contacts where vaccination is contraindicated. However, the concentration of measles-specific antibodies in NHIG depends on antibody levels within pooled donor plasma. There are concerns that measles immunity in the Australian population may be declining over time and that blood donors' levels will progressively decrease, impacting levels required to produce effective NHIG for measles PEP.
View Article and Find Full Text PDFPersistence of Antibodies against Measles, Mumps, and Rubella after the Two-Dose MMR Vaccination: A 7-Year Follow-Up Study.
Vaccines (Basel)
July 2024
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
In 2014, the Expanded Program on Immunization of Thailand changed the timing of the second dose of the measles-mumps-rubella (MMR) vaccine from 4-6 years to 2.5 years, while maintaining the first dose at 9 months of age. This study aimed to examine the dynamics and durability of immune responses induced by the two-dose MMR vaccine in a group of 169 Thai children from 4 to 7 years of age (4.
View Article and Find Full Text PDFSeroprevalence of measles antibodies in the Italian general population in 2019-2020.
Vaccine
September 2024
National Coordinator of the Working Group "Vaccines and Immunization Policies", Italian Society of Hygiene, Preventive Medicine and Public Health, Italy.
Article Synopsis
- Italy has seen a significant drop in measles cases but hasn't yet eliminated the disease, prompting a study on the prevalence of anti-measles antibodies in various demographics.
- A total of 3746 serum samples from healthy individuals aged 6-64 were analyzed, revealing an overall anti-measles IgG seroprevalence of 91.2%, with higher rates in younger (94.2%) and older (97.6%) age groups.
- There is notable regional variation in seroprevalence, with higher levels in the South (93.2%) compared to Northern-Central Italy (88.9%), highlighting the need for ongoing vaccination efforts to prevent future outbreaks.
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